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您当前位置:苏州大学骨科研究所 >> 科研团队 >> 李斌团队 >> 浏览图片

姓名

李斌

 

性别

电话

051267781163

传真

051267781163

职称

 特聘教授,博士生导师

职务

 

Email

binli@suda.edu.cn

办公地址

苏州大学南校区1号楼308

个人简介

1996年毕业于清华大学化学工程系高分子材料与化工专业。2001年获清华大学材料学工学博士学位。20012004在新加坡材料工程研究院(Institute of Materials Research and Engineering)任副研究员。20052009在美国匹兹堡大学(University of Pittsburgh)医学院骨科系任博士后副研究员。并于2004 年和2009年分别在美国卡内基-梅隆大学(Carnegie Mellon University)机械工程系和哈佛大学(Harvard University)公共卫生学院从事为期3月的短期访问研究。20099月至今在苏州大学骨科研究所任职,现为苏州大学特聘教授、博士生导师、骨科研究所生物材料与细胞力学实验室负责人。历获法国驻华大使馆“徐光启”项目、法国驻上海领事馆“法国科研创新人才工程”、苏州市引进紧缺高层次人才计划、美国骨科研究协会“新研究者识别”入围奖等奖励。作为Program Committee执行成员,组织在美国夏威夷召开第25SPRBM年会(2007)。作为组委会主席,组织在苏州召开由ASBMR (美国骨矿研究学会) ICMRS(国际华人骨研学会)共同举办的第一届国际华人骨科研究大会(2013)。现任或曾任Journal of Orthopaedic Translation Chemical SensorsInternational Journal of Orthopaedics、中国组织工程研究、苏州大学学报(医学版)等学术期刊编委。挂职江苏艾迪尔医疗科技股份有限公司,担任技术顾问。应邀在国际和国内学术会议做Keynote报告2次、邀请报告11次,应邀在国内外作学术讲座15次,组织及主持国际和国内学术会议分会10次。担任国家自然科学基金、中国博士后科学基金、莙政基金等评审专家。担任二十余家学术期刊评审人。已发表论文56篇(其中SCI收录43篇),参编专著8部。

 

研究方向

l  骨、软骨修复材料

l  干细胞与组织工程

l  智能化分子识别与可控释放

l  材料表面功能化修饰

l  细胞生物力学和力学生物学

 

承担的科研项目

l 面向具有原位成骨活性植入材料制备的表面引发蛋白印迹聚合研究。国家自然科学基金面上项目 (项目批准号 81471790), 2015-012018-12项目主持人。

l 基于弹性模量梯度支架和纤维环源干细胞的组织工程纤维环构建和功能研究。国家自然科学基金面上项目 (项目批准号81171479), 2012-012015-12项目主持人

获得荣誉及奖励

2011 Xu Guangqi Program. Office of Science and Technology, French Embassy in China

2010 France Talent Innovation Award. Science and Technology Office, Consulate General of France in Shanghai      

代表性论文

1.     L. Zhou, C-H. Zhu, L. Edmonds, H-L. Yang, W-G. Cui*, B. Li*. Microsol-electrospinning for controlled loading and release of water-soluble drugs in nanofibrous membranes. RSC Advances, accepted.

2.     Q-P. Guo, J. Li, C. Liu, S-H. Wang, Y-B. Wang, B. Li*, H-L. Yang*. Identification of rabbit annulus fibrosus-derived stem cells. PLoS One, accepted.

3.     G-Q. Pan*, B-B. Guo, Y. Ma, W-G. Cui, F. He, B. Li*, H-L. Yang, K. J. Shea. Dynamic introduction of cell adhesive factor via reversible multicovalent phenylboronic acid/cis-diol polymeric complexes. J Am Chem Soc 2014, 136(17): 6203-6206.

4.     C-B. Cao, H. Li, J. Li, C. Liu, H-L. Yang*, B. Li*. Mechanical reinforcement of injectable calcium phosphate cement/silk fibroin (SF) composite by mineralized SF. Ceram Int 2014, 40: 13987-13993.

5.     J. Li, C. Liu, Q-P. Guo, H-L. Yang, B. Li*. Regional variations in the cellular, biochemical, and biomechanical characteristics of rabbit annulus fibrosus. PLoS One 2014, 9(3): e91799.

6.     G-Q. Pan*, Q-P. Guo, Y. Ma, H-L. Yang, B. Li*. Thermo-responsive hydrogel layers imprinted with RGDS peptide: a system for harvesting cell sheets. Angew Chem Int Ed 2013, 52(27): 6907-6911.

7.     G-Q. Pan, Q-P. Guo, C-B. Cao, H-L. Yang, B. Li*. Thermo-responsive molecularly imprinted nanogels for specific recognition and controlled release of proteins. Soft Matter 2013, 9 (14): 3840-3850.

8.     J-Y. Zhang, B. Li*, J. H-C. Wang*. The role of engineered tendon matrix in the stemness of tendon stem cells in vitro and the promotion of tendon-like tissue formation in vivo. Biomaterials 2011, 32(29): 6972-6981.

9.     B. Li, J. H-C. Wang. Fibroblasts and myofibroblasts in wound healing: Force generation and measurement. J Tissue Viability 2011, 20(4): 108-120.

10.  B. Li, F. Li, K. M. Puskar, J. H-C. Wang. Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude. J Biomech 2009, 42(11): 1622-1627.

11.  B. Li, M. Lin, Y. Tang, B. Wang, J. H-C. Wang. A novel functional assessment of the differentiation of micropatterned muscle cells. J Biomech 2008, 41(16): 3349-3353.

12.  B. Li, L. Xie, Z. C. Starr, Z-C. Yang, J-S. Lin, J. H-C Wang. Development of micropost force sensor array with culture experiments for determination of cell traction forces. Cell Motil Cytoskel 2007, 64(7): 509-518.  (Renamed to Cytoskeleton in 2010)

13.  B. Li, J-X. Chen, J. H-C. Wang. RGD peptide-conjugated poly(dimethylsiloxane) promotes adhesion, proliferation, and collagen secretion of human fibroblasts. J Biomed Mater Res A 2006, 79A(4): 989-998.

14.  B. Li, Y-X. Ma, S. Wang, P. M. Moran. Influence of carboxyl group density on neuron cell attachment and differentiation behavior: gradient-guided neurite outgrowth. Biomaterials 2005, 26(24): 4956-4963.

15.  B. Li, Y-X. Ma, S. Wang, P. M. Moran. A technique for preparing protein gradients on polymeric surfaces: effects on PC12 pheochromocytoma cells. Biomaterials 2005, 26(13): 1487-1495.

 

出版专著

1.       J. H-C. Wang*, B. Li*. Mechanobiology of Cell-Matrix Interactions. In: E. A. Balazs (Ed.), Structure and Function of Biomatrix: Control of Cell Behavior and Gene Expression. Chapter 8, pp. 253-292. Matrix Biology Institute, Edgewater, NJ, USA, 2012.

2.       B. Li, J-S. Lin, J. H-C. Wang. Cell Mechanobiology: The Forces Applied to Cells and Generated by Cells. In J. Nagatomi (Ed.), Mechanobiology Handbook. Chapter 12, pp. 253-276. CRC Press, Boca Raton, FL, USA, 2011.

3.       J. H-C. Wang and B. Li. The Principles and Biological Applications of Cell Traction Force Microscopy. In A. Méndez-Vilas and J. Díaz (Ed.), Microscopy: Science, Technology, Applications and Education. Microscopy Book Series - Number 4, Vol. 1, pp. 449-458. FORMATEX Research Center, Badajoz, Spain, 2010.

4.       J. H-C. Wang, B. Li. Application of Cell Traction Force Microscopy for Cell Biology Research.  In: R. H. Gavin (Ed.), Cytoskeleton Methods and Protocols- Methods in Molecular Biology Series, Vol. 586, Chapter 17, pp. 301-313. The Humana Press Inc, New York, USA, 2009.

5.       J. H-C. Wang, J. Chen, B. Li, B. P. Thampatty. Cell Traction Force: Generation, Transmission, Regulation, and Measurement. In: L. F. Greco and A. L. Martino (Ed.), Signal Transduction: New Research. Chapter 3, pp. 69-84. Nova Science Publishers, Hauppauge, USA, 2008.

6.       J. H-C. Wang, B. Li, J-S. Lin. Cell Traction Force Microscopy for Musculoskeletal Research. In: K-S. Leung, et al. (Ed.), A Practical Manual for Musculoskeletal Research. Chapter 44, pp.773-787. World Scientific Publishing, Hackensack, USA, 2008.

 

学会任职

l  International Chinese Musculoskeletal Research Society (ICMRS, 国际华人骨研学会), Member-at-Large of the Board of Directors (董事会常务委员)

l  ICMRS, China Development Committee(中国发展委员会),委员

l  中华医学会骨科分会基础学组,委员

l  中国医师协会骨科医师分会骨科基础工作委员会,委员

l  中国康复医学会修复重建专业委员会基础与材料学组,委员

l  Journal of Orthopaedic TranslationEditorial Board member

l  International Journal of OrthopaedicsEditorial Board member

 

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