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美国哥伦比亚大学Christopher Jacobs教授来我所交流访问

201688日,苏州大学骨科研究所邀请了美国哥伦比亚大学Christopher Jacobs教授来我所交流访问并做专题报告,研究所教职工及研究生参加了该系列报告。

         Christopher Jacobs教授的报告题目为Primary Cilia Biomechanics Regulates Mechanosensing and Bone Regeneration(初级纤毛生物力学调控力学感应及骨再生)。细胞对的力学刺激的感应对于骨质疏松等疾病的发生具有关键作用,然而目前相关机制知之甚少。最新研究表明,胞外表达的初级纤毛对于细胞感受物理及化学信号具有重要作用。Jacobs教授的课题组发现在骨组织中,初级纤毛可感受外界的力学信号。条件性敲除初级纤毛后,明显影响了细胞对力学刺激的响应。通过结合实验与建模,其研究发现,当受外力刺激时,初级纤毛本身结构及其与微管骨架的锚着点的结构均发生了变形或重塑。同时Jacobs教授的研究也从分子机制上阐述了力学信号通过初级纤毛引发的信号通路。该研究结果为深入研究细胞生物力学提供了新的线索,同时也对骨代谢疾病及骨组织重建提供了新的靶点与思路。

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          Christopher Jacobs教授对初级纤毛与细胞力学响应进行了深入研究,引起大家的广泛兴趣。会后,多位听众与Jacobs教授进行了热烈的讨论。

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附:学者简介

Dr. Christopher Jacobs received in PhD in Mechanical Engineering in 1994 from Stanford University and served as a faculty member there until 2008 when he joined the Biomedical Engineering Department at Columbia University. The goal of his lab is to investigate cellular mechanosensing, particularly in the skeleton, with tightly coupled integration of advanced theoretical mechanics and modern molecular biology. He has made discoveries in terms of the mechanical signals that bone cells sense and respond to and how these responses are communicated and integrated between cells. This has directly brought them to their current research question, understanding novel mechanisms for how these signals are transduced at a cellular level. Most recently his lab has identified primary cilia, enigmatic structures found in virtually all cell types, as a mechanosensor both in vitro and in vivo. They are currently investigating the mechanisms of intracellular signaling initiated by primary cilia with novel molecular biology strategies and relating those events to primary cilia biomechanical behavior and properties. To date he has been awarded over $7.5 million from federal and state agencies including for individual investigator projects, as well as $9.5 million in center grants. He has published over 100 peer-reviewed papers, 2 books, and 9 book chapters. He is the senior author of the innovative textbook “Introduction to Cell Mechanics and Mechanobiology”, which has been adopted in 35 courses with an enrollment of over 850 students worldwide since it publication in 2013. He has received research awards from the European and American Societies of Biomechanics, and was the winner of the Skalak Award for the best paper published in 2015 in the Journal of Biomechanical Engineering. He was the 2014 recipient of the Van C. Mow medal from the American Society of Mechanical Engineers.

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