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南方科技大学肖国芝教授来我所交流访问

      2017322日,苏州大学骨科研究所邀请了南方科技大学肖国芝教授来我所交流访问并做专题报告,研究所教职工及骨科研究生参加了该报告。

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   肖教授的报告题目为“Critical Role of Kindlin-2 in Skeletal Development and Homeostasis”(Kindlin-2蛋白在骨骼发育及稳态中的关键性作用)。他从骨生物学角度出发,首先总结并概述了骨生物学中重要的转录因子如Sox9Runx2Osterix及相关通路Wnt在骨/软骨功能、软/软骨发育及稳态中的功能与作用。其后,他介绍了其团队所发现的Kindlin-2蛋白在骨发育与稳态中的关键性作用及相关的信号通路,为骨关节炎及骨质疏松等疾病的发生发展提供了新的机制,有望为骨关节炎的有效治疗提供新的靶点,引起了大家热烈讨论。

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附:学者简介

Professor Guozhi Xiao is an internationally renowned bone biologist. Dr. Xiao obtained his PhD degree in biochemistry and molecular biology from Peking University in 1994. He did his post-doc training (1994-1998) and worked as a research scientist (1998-2005) at the University of Michigan Ann Arbor. In 2005, he assumed an independent faculty position as a tenure-track assistant professor at the University of Pittsburgh School of Medicine and was promoted to the level of associate professor with tenure in 2011. In 2012, he joined Rush University Medical Center in Chicago and assumed a prominent academic position as the Dr. Ralph and Marian C. Falk Endowed Chair Professor of Biochemistry and served as the director of research of the department of biochemistry. In 2013, he joined the SUSTech as a tenured full professor and later became the chair of the biological department. Dr. Xiao has made several contributions to our understanding the molecular control of skeletal development and homeostasis. His work is reported in more than 100 peer-reviewed publications, many in high profile journals such as the Journal of Clinical Investigation and Nature Communications. He serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and sits on the editorial boards of the Journal of Bone and Mineral Research (JBMR) and the Journal of Biological Chemistry (JBC). Dr. Xiao’s research interests focus in the following areas: (1) To determine how osteoblast, osteoclast, and chondrocyte formation is controlled during skeletal development and homeostasis under physiological and pathological conditions. (2) To define the mechanisms that modulate bone angiogenesis. (3) To study the bone-muscle interactions. By working on these projects, Xiao laboratory has also maintained a focus on important medical issues involving bone – osteoporosis, osteoarthritis, metastatic osteolytic lesions, and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.

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