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骨科研究所学术报告:Reactive 3D Bioprinting of Stem Cells and Hydrogels for Soft Tissue Engineering
时间:2017年09月01日 作者:岳秀飞 编辑:岳秀飞 加入收藏

报告题目:Reactive 3D Bioprinting of Stem Cells and Hydrogels for Soft Tissue Engineering

报告时间:201794日(周一)1030

报告地点:苏州大学南校区1号楼3楼骨科研究所317学术报告厅
报告人:Wenmiao (Will) Shu教授(英国斯特拉斯克莱德大学)

 

摘要:

Human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells, can be potentially turned into any cell type in our body and self-renew indefinitely to enable large populations of cells to be expanded in vitro. These unique characteristics make pluripotent stem cells as one of the ideal cell sources for use in a number of tissue engineering applications, from creating scalable human tissue models for novel drug discovery and drug toxicity testing to on-demand tissue/organ regeneration. One of the key challenges in 3D bioprinting is to gently dispense or extrude highly viscious hydrogel materials while preventing the delicate biological cells from damages by shear stress.  This talk will give an overview of our efforts in 3D bioprinting of hPSCs including the development of a reactive 3D bioprinting techniques, printable novel hydrogel based bioinks and 3D stem cell differentiation.  Although there are exciting early success in bioprinting of hPSCs and their derived cells such as hepatocytes and cardiomyocytes, significant challenges and opportunities remain to be explored in the interface between 3D biofabrication, biomaterials and regenerative medicine to produce more realistic hPSCs-derived human tissues for in-vitro models and transplantable tissues towards the ultimate aim of organ printing.

 

报告人简介:

Professor Wenmiao (Will) Shu is the Hay Professor in Biomedical Engineering at the University of Strathclyde (Glasgow). He obtained his PhD at the Engineering Department from University of Cambridge, UK. His research interests cover a range of biomedical engineering topics including 3D biofabrication, biosensors, microsystems and their applications for regenerative medicine. He led the research to demonstrate the first bioprinting of human embryonic stem cells (h-ESCs) and human induced pluripotent stem cells (h-iPSCs), paving the way for their applications on animal-free drug testing and 3D printed organs. He held a visiting position at Stanford University. He is an editorial board member for IOP Biofabrication Journal and serves as a board director of the International Society for Biofabrication (ISBF).