报告题目：Multiscale biomaterials for stem cell-based tissue regeneration
报告时间：2017年11月1日（周三）16：00
报告地点：苏州大学南校区1号楼3楼骨科研究所307学术报告厅
报 告 人：边黎明教授（香港中文大学）
摘要：
Recent research progress demonstrates the promising potential of biomaterials for a variety of applications such as 3D cell culture, drug/gene delivery, and molecular imaging. These applications are not only valuable to assisting fundamental biomedical research but also instrumental to advancing clinical therapies. Biomaterials are generally categorized into two large groups, i.e., bulk scaffold biomaterials and nanoscale biomaterials. Bulk biomaterials such as hydrogels provide a conducive 3D environment to support the maintenance of cell phenotype and ECM deposition. Functionalization of bulk biomaterials with bioactive ligands influences seeded cells via ligation with the targeted membranous receptors via an “outside-in” approach to regulate cells by biomaterials. However, it is challenging for bulk biomaterials to directly influence intracellular targets to regulate cellular behaviors. Nanoscale biomaterials that are capable of entering stem cells are effective vehicles to deliver drugs/genes to intracellular space, thereby mediating desired cellular activities. Moreover, this intracellular delivery can be controlled at selected time points and locations by prescribed stimuli in vivo. Nanomaterials with sensing motifs also enable detection of key biomarkers associated with cellular events (e.g. stem cell differentiation) in living cells in vitro or in vivo, thereby providing real-time information on the dynamic cellular behaviors. These unique advantages of nanomaterials for mediating intracellular functions complement the bulk scaffold biomaterials by regulating cells via an “inside out” approach. This talk focuses on our recent work on developing multiscale biomaterials for stem cell-mediated repair/regeneration of diseased and injured tissues.
报告人简介：
Dr. Bian received his B.Eng and M.Sc degree from the National University of Singapore in 2002 and 2004, respectively. Dr. Bian completed his Ph.D. study in Biomedical Engineering at Columbia University in 2009. Dr. Liming Bian then conducted his postdoctoral research in the Department of Bioengineering, the University of Pennsylvania from 2009 to 2012. In 2012, Dr. Bian joined the Chinese University of Hong Kong as an assistant professor. Dr. Bian’s research focuses on the development of novel multiscale biomaterials not only for investigating the role of cell microenvironment factors on stem cell behaviors but also for facilitating the regeneration of diseased or injured tissues and organs. Dr. Bian’s research work has been published in the leading journals including PNAS, JACS, Nano Letters, Biomaterials, Advanced Functional Materials, ACS Nano, Macromolecules, Advanced Healthcare Materials, etc.
