徐勇

徐勇

邮箱地址：yxu1615@suda.edu.cn

获得荣誉：

国家级青年人才项目

江苏特聘教授，苏州市姑苏领军人才，江苏省科技副总

苏州大学东吴特聘教授 拔尖人才 

苏州大学骨科研究所教授 博士生导师 博士后合作导师 PI

苏州大学附属第一医院&附属第三医院 双聘教授

苏州工业园区生物医药创新集群博士后导师

江苏省青年科技工作者协会生物医药专委会委员

江苏省侨联侨界专家委员会特聘专家

苏州市侨联侨界创新联盟智库专家

江苏省免疫学会组织修复与免疫专委会常务委员

中国农工民主党苏州大学第二支部主任委员

苏州先觉新材料科技有限公司 联合创始人&技术负责人

学习经历：

2008年09月-2012年06月     中国       本科         南通大学              生物技术           

2012年07月-2014年07月     中国       硕士         中山大学              生物医学工程          

2014年10月-2019年10月     德国       博士    德累斯顿工业大学     骨医用材料与骨组织工程     

工作经历：

2019年5月-2022年7月     德国     德累斯顿工业大学     博士后

2022年7月-至今               中国           苏州大学             教授         

研究方向：

骨外科学 再生医学 骨疾病与诊疗一体 器官组织修复 3D生物打印 药物高通量筛选 生物医用水凝胶 转化医学 医用器械材料科

个人介绍：

2014至2022年，于德国精英大学——德累斯顿工业大学获得博士学位，并在德国一流的生物医学与生物医用高分子材料研究团队从事博士后研究，师从欧洲知名生物材料专家Yixin Zhang教授与德国工程院院士Carsten Werner教授。近年来，研究工作始终围绕“骨疾病治疗机制探索—ECM微环境调控—骨组织修复应用”这一关键科学问题展开。以第一作者或通讯作者身份在Nature Communications、Advanced Science、Biomaterials、Journal of Controlled Release等国际高水平SCI期刊发表论文30篇。

2022年7月回国后，主持多项国家自然科学基金、江苏省自然科学基金，以及国家级、江苏省及苏州市人才项目。已获授权国内专利10项，美国及欧洲国际专利3项。相关研究成果成功实现产业转化，曾获德国联邦教研部科研转化孵化计划“EXIST-Forschungstransfer”资助（资助金额200万欧元），并于2019年在德国注册成立生物科技公司“denovoMATRIX”，其产品已投入市场，为多家医药及干细胞公司提供安全、稳定、高效的干细胞扩增与定向分化基质表面产品。

目前，研究重点聚焦于“细胞外基质调控肌肉—骨骼系统难愈性损伤再生修复机制”，深入探索细胞外基质通过调控线粒体能量代谢、免疫微环境及细胞内外氧化还原平衡等途径促进组织再生的分子机制，为肌肉—骨骼损伤修复提供新靶点。相关成果已在苏州实现产业转化，推动创新型生物材料与医疗器械的“产学研医教”协同创新，为运动系统组织再生与器官制造领域提供新思路与技术路径。2023年1月，在苏州工业园区BioBay共同创办先觉新材料科技有限公司（https://xjmatrix.com/），注册资本1000万元人民币，担任公司共同创始人兼技术负责人，专注于创新型生物材料与医疗器械的研发与转化。

科研项目：

近五年代表作：

[1] Yong Xu, Rebecca Rothe, Dagmar Voigt, Sandra Hauser, Meiying Cui, Takuya Miyagawa, Michelle Patino Gaillez , Thomas Kurth , Martin Bornhäuser, Jens Pietzsch* and Yixin Zhang*.Convergent synthesis of diversified reversible network leads to liquid metal-containing conductive hydrogel adhesives. Nature communications, 12(1), 1-19. (2021). (第一作者, IF 17.694，分区: I区)

[2] Yilin Yang, Jiangbo Guo, Haifei Cao, Xin Tian, Hao Shen, Junjie Niu, Huilin Yang*, Qin Shi*, Yong Xu*. "Seeds-and-Soil Inspired Hydrogel Microspheres: A Dual-Action Antioxidant and Cellular Therapy for Reversing Intervertebral Disc Degeneration." Biomaterials (2025): 123326. (末位通讯作者, IF =12，分区: I区)

[3] Xin Tian, Yan Miao, Hao Liu, Chenyang Jin, Tao Liu , Wenge Ding*, Fan He*, Yong Xu* "Bioinspired hydrogel microspheres enhance nucleus pulposus regeneration through N-cadherin interaction with extracellular matrix mimicry." Journal of Controlled Release (2025): 113771. (末位通讯作者, IF =10.8，分区: I区)

[4] XinTian,ChenyangJin,YanMiao,HaoLiu,XiChen,Wenge Ding*, Fan He*, Yong Xu* Dynamic Dual-Network Hydrogel Microspheres for Enhanced Nucleus Pulposus Regeneration via Extracellular Matrix Mimicry. Composites Part B: Engineering (2025) .112715.(末位通讯作者, IF =12.4，分区: I区)

[5] Xiaoyang Ge, Yesheng Jin, Jingyuan He, Zhihao Jia*, Ying Liu*, Yong Xu* Extracellular matrix in skeletal muscle injury and atrophy: mechanisms and therapeutic implications. Journal of Orthopaedic Translation (2025),404-418,52. (末位通讯作者, IF = 7.8，分区: I区)

[6] Yang Liu,Yijian Zhang, Chenqi Yu,Xiaowei Xia, Kang kang,Yubin Wu, Yaoge Deng, Jianfeng Yu, Mingzhuang Hou,Zhiwen Luo, Huilin Yang*, Yong Xu*, Xuesong Zhu*，“Three birds with one stone” modified organic diselenide hydrogel microspheres for the treatment of osteoarthritis. Nature communications (2025). (共同通讯作者, IF =15.7，分区: I区)

2022年7月入职苏州大学后, 以第一或通讯作者（含共同）发表中科院一区论文：

[7] Can Huang, Lanlan Dong, Baohua Zhao, Yifei Lu, Shurun Huang, Zhiqiang Yuan, Gaoxing Luo*, Yong Xu*, Wei Qian*. Anti-inflammatory hydrogel dressings and skin wound healing. Clinical and Translational Medicine, 12(11), e1094. (2022). (共同通讯作者, IF = 10.6，分区: I区)

[8] X Xia, Y Liu, Y Lu, J Liu, Y Deng, Y Wu, M Hou, F He, H Yang, Y Xu*, Y Zhang*, X Zhu* Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3‐energized And Microenvironment‐Modulated Hydrogel Microspheres to Impede Osteoarthritis. Advanced Healthcare Materials (2023): 2302475 (共同通讯作者, IF = 11.092，分区: I区)

[9] X Hu, Xin Tian, C Yang, F Ling, H Liu, X Zhu, M Pei, H Yang , T Liu, Y Xu*, F He*. Melatonin-loaded self-healing hydrogel targets mitochondrial energy metabolism and promotes annulus fibrosus regeneration. Materials Today Bio (2023): 100811. (共同通讯作者, IF = 8.2，分区: I区)

[10] Can Huang, Lanlan Dong, Baohua Zhao, Shurun Huang, Yifei Lu, Xiaorong Zhang, Xiaohong Hu, Yong Huang, Weifeng He, Yong Xu*, Wei Qian* & Gaoxing Luo*. Tunable Sulfated Alginate-based Hydrogel Platform with enhanced anti-inflammatory and antioxidant capacity for promoting burn wound repair." Journal of Nanobiotechnology 21.1 (2023): 387. (共同通讯作者, IF = 10.2,分区: I区)

[11] Zhangzhe Zhou, Yang Liu, Wenjing Li, Zhijian Zhao, Xiaowei Xia, Junlin Liu, Yaoge Deng, Yubin Wu, Xiangqiang Pan, Fan He, Huilin Yang, Weihong Lu*, Yong Xu*, Xuesong Zhu*. A Self‐Adaptive Biomimetic Periosteum Employing Nitric Oxide Release for Augmenting Angiogenesis in Bone Defect Regeneration[J]. Advanced Healthcare Materials, 2023: 2302153. (共同通讯作者, IF = 10,分区: I区)

[12]  H Liu, X Tian, C Jin, Y Li, X Zhu, M Pei, T Liu, H Yang*, Y Xu*, F He* Delivering cells via ECM mimetic hydrogel microspheres for promoting the reconstruction of rat lumbar nucleus pulposus." Chemical Engineering Journal (2024): 150212. (共同通讯作者, IF = 15.1,分区: I区)J Liu, Z Zhou, M Hou, X Xia, Y Liu, Z Zhao, Y Wu, Y Deng, Y Zhang, F He*, Y Xu*, X Zhu*. Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration[J]. Materials Today Bio, 2024, 25: 100956. (共同通讯作者, IF = 8.2,分区: I区)

[13] Xiaoyang Ge, Chengyue Wang, Guanyu Yang, Dimulati Maimaiti, Mingzhuang Hou, Hao Liu, Huilin Yang, Xi Chen, Yong Xu*, Fan He*. Enhancement of mitochondrial energy metabolism by melatonin promotes vascularized skeletal muscle regeneration in a volumetric muscle loss model[J]. Free Radical Biology and Medicine, 2024. (共同通讯作者, IF =7.4分区: I区)

[14] B Zhang, Z Zhou, Y Zhang, Y Miu, C Jin, W Ding, G Zhao, Yong Xu*. A sugary solution: Harnessing polysaccharide-based materials for osteoporosis treatment. Carbohydrate Polymers (2024): 122549. (末位通讯作者, IF = 10.7分区: I区)

[15] J Chen, X Zhou, Y Li, T Liu, W Ding, F He, Yong Xu*. Transforming Osteoarthritis Treatment: Embracing Hydrogel Microspheres. ACS Materials Letters 6.8 (2024): 3862-3882. (末位通讯作者, IF = 9.6分区: I区)

[16] M Hou, Y Deng, N Lv, Y Wu, Y Zhu, Y Zhang, Y Liu, X Xia, C Yu, J Yu, F He*, Yong Xu*, X Zhu* Cyclic amplification of remodeling bone regeneration process via cerium-energized spinning hydrogel biomembrane for rescuing osteoporotic bone defects. Chemical Engineering Journal 492 (2024): 152262. (共同通讯作者, IF = 15.1,分区: I区)

[17] Rebecca Rothe^#, Yong Xu^#, Johanna Wodtke, Florian Brandt, Sebastian Meister, Markus Laube, Pier‐Luigi Lollini, Yixin Zhang, Jens Pietzsch, Sandra Hauser. Programmable Release of Chemotherapeutics from Ferrocene‐Based Injectable Hydrogels Slows Melanoma Growth. Advanced Healthcare Materials (2024): 2400265. (共同第一作者, IF = 10,分区: I区)

[18]  Xiaozhen Liu，Zhuozhuo Ren，Xuli Meng* & Yong Xu*. Substrate topography regulates extracellular matrix component secretion by bone marrow-derived mesenchymal stem cells. Journal of Science: Advanced Materials and Devices, 100437. (2022). (通讯作者, IF = 7.382，分区: II区)

[19] Wei He, Xin Tian, Quan Zhou, Jiaheng Lv, Yangfeng Li, Chenyang Jin, Hao Liu, Huiling Yang, Yong Xu*, Fan He* & Tao Liu* Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells. J Nanobiotechnol 22, 634 (2024). (共同通讯作者, IF = 10.6，分区: I区)

[20] Dimulati Maimaiti, Xiaoyang Ge, Chengyue Wang, Jinuo Liu, Guanyu Yang, Dachuan Zhang, Yong Xu*, Fan He*, Xi Chen*. Extracellular matrix-mimicking cryogels composed of methacrylated fucoidan enhance vascularized skeletal muscle regeneration following volumetric muscle loss. International Journal of Biological Macromolecules 283 (2024): 137122. (共同通讯作者, IF = 7.7，分区: I区)

[21] X Wang, Y Huang, Y Yang, X Tian, Y Jin, W Jiang, H He*, Y Xu*, Y Liu*. Polysaccharide-Based Biomaterials for Regenerative Therapy in Intervertebral Disc Degeneration. Materials Today Bio (2024): 101395. (共同通讯作者, IF = 8.7，分区: I区)

[22] Zhiyang Ren, Shuhan Tang, Jia Wang, Shuqing Lv, Kai Zheng*, Yong Xu*, Ke Li*. Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations. Biomaterials Research 29 (2025): 0134. (共同通讯作者, IF = 8.1，分区: I区)

[23] Q Hou, X He, M Guo, X Li, Z Zhang, X Xu, Y Xu*, Q Shi*, Y Han* . Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding." Journal of Nanobiotechnology 23.1 (2025): 1-19. (共同通讯作者, IF = 10.6，分区: I区)

[24] X Zhou, X Tian, J Chen, Y Li, N Lv, H Liu, T Liu, H Yang, X Chen*, Y Xu*, F He*. Youthful Stem Cell Microenvironments: Rejuvenating Aged Bone Repair Through Mitochondrial Homeostasis Remodeling. Advanced Science (2025): 2409644. (共同通讯作者, IF = 14.44，分区: I区)

[25] S Zhao, X Hu, Y Zhao, Y Zhang, Y Jin, F Hua*, Y Xu*, W Ding*. Hydrogel-based therapies for diabetic foot ulcers: recent developments and clinical implications." Burns & Trauma 13 (2025): tkae084. (共同通讯作者, IF =6.3，分区: I区)

[26] Can Huang, Yijie Liu, Baohua Zhao, Mengjun He, Shurun Huang, Lanlan Dong, Yifei Lu, Guangyun Hu, Xiaoqing Zhou, Yong Xu*, Wei Qian*, Gaoxing Luo*. Dual-Response Hydrogel System Coordinating Immunomodulation and Tissue Repair for Promoting Infected Burn Wound Healing. ACS Materials Letters, 2025, 7: 489-499. (共同通讯作者, IF =9.9，分区: I区)

[27] Junqi Dai, Li Ni , Chenyang Jin , Xin Tian , Yujie Shen , Yan Miao, Yong Xu* , Fan He* , Huilin Yang* Esterase-responsive kartogenin composite hydrogel microspheres boost nucleus pulposus regeneration in intervertebral disc degeneration. Acta Biomaterialia 2025 (共同通讯作者, IF =9.4，分区: I区)

[28] Feng Ling , Xiayu Hu, Yujie Shen, Xi Chen, Zonglai Qian, Hao Liu*, Yong Xu*, Fan He* Polysaccharide hydrogel-reinforced nanofibrous composite promotes annulus fibrosus regeneration by regulating mitochondrial antioxidant and metabolic functions. Chemical Engineering Journal (2025),164696. (共同通讯作者, IF =13.2，分区: I区)

[29] Xu He, Xingzhi Liu, Xinyi Cheng, Can Zhu, Yida Chen, Yi Wang, Yun Zhou, Hao Shen, Huilin Yang, Yong Xu*, Qin Shi*, Junjie Niu* Bionic bearing-inspired lubricating microspheres with immunomodulatory effects for osteoarthritis therapy. Journal of Nanobiotechnology 23, 457 (2025). (共同通讯作者, IF = 12.6，分区: I区)

[30] Can Liu^#, Runqi Wang^#, Yong Xu^#, Qingyi Liu, Yin Li, Xiangpeng Liu, Hui Shu, Kaige Gao,  Xingye Zheng, Yingying Dong, Yijun Wang, Bin Guo, Lei Fu, Bin Zhang, Liang Zhao, Zhihao Jia,  Xiaobo Sun， Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch Signaling. iMeta (2025) e70074. (共同第一作者, IF = 33.2，分区: I区)

[31] Jin, Chenyang, Jianan Chen, Yan Miao, Xin Tian, Jia Wang, Fan He*, Yijie Liu*, and Yong Xu*. "Cuttlefish Ink Nanoparticle-Engineered Hydrogel Microspheres Synergistically Attenuate Disc Degeneration via Antioxidant Defense and Matrix Synthesis Activation." Materials Today Bio (2025): 102244. (末位通讯作者, IF =10.2，分区: I区)

[32] Ma, Ruikai, Shuao Zhao, Yesheng Jin, Yinhao Li, Huxin Tang, Mingyang Hu, Xinyu Hu*, Yong Xu*, and Wenge Ding*. "Advancing biomaterial innovation for tissue engineering through microbial synthetic biology: A review." International Journal of Biological Macromolecules (2025): 146771. (共同通讯作者, IF =8.5，分区: II区)

[33] Jin, Yesheng, Yixue Huang, Jia Wang, Xinfeng Zhou, Jianan Chen, Wenge Ding*, Zhihao Jia*, and Yong Xu*. "From Injury to Integrity: Tissue Engineering Solutions in Combined Bone Repair and Regeneration and Muscle Repair." Burns & Trauma (2025): tkaf052. (末位通讯作者, IF =9.6，分区: II区)

[34] Yesheng Jina, Shuqing Lv，Nanning Lv, Yixue Huanga, Jia Wang, Yun Xiao, Xinfeng Zhou,  Yanxia Ma , Gang Zhao,*, Fan He,*, Yong Xu,* Multi-scale biomimetic fusion construction of cerium ion hydrogel-scaffold for promoting osteoporotic bone defect repair. Journal of Orthopaedic Translation 55 (2025): 172-191. (末位通讯作者, IF =7.8，分区: I区)

[35] Jiaheng Lv, Yujie Shen, Quan Zhou, Wei He, Yulin Chen, Xi Chen, Huilin Yang, Yong Xu*, Fan He*, Tao Liu*，Selenium-functionalized hydrogel microspheres promote nucleus pulposus reconstruction by activating selenoprotein-mediated mitochondrial redox homeostasis and energy metabolism. Biomaterials (2025): 123826. (共同通讯作者, IF =12，分区: I区)

第一作者代表性论著（2018-2023）：

[36] Yong Xu*, Rebecca Rothe, Dagmar Voigt, Ahmed Sayed, Can Huang, Sandra Hauser, Pao-Wan Lee, Meiying Cui, James P. Sáenz, Aldo R. Boccaccini, Kai Zheng*, Jens Pietzsch*, and Yixin Zhang* A self-assembled dynamic extracellular matrix-like hydrogel system with multi-scale structures for cell bioengineering applications. Acta Biomaterialia, (2023). (第一作者&共同通讯作者, IF 10.633，分区:  I区)

[37] Yong Xu*, Michelle Patino Gaillez, Kai Zheng, Dagmar Voigt, Meiying Cui, Thomas Kurth, Lingfei Xiao, Rebecca Rothe, Sandra Hauser, Pao-Wan Lee, Robert Wieduwild, Weilin Lin, Martin Bornhäuser, Jens Pietzsch, Aldo R. Boccaccini, and Yixin Zhang*. A Self‐Assembled Matrix System for Cell‐Bioengineering Applications in Different Dimensions, Scales, and Geometries. Small, 2104758. (2022). (第一作者&共同通讯作者, IF15.153，分区: I区)

[38] Yong Xu, Panagiotis A. Patsis, Sandra Hauser, Dagmar Voigt, Rebecca Rothe, Markus Günther, Meiying Cui, Xuegeng Yang, Robert Wieduwild, Kerstin Eckert, Christoph Neinhuis, Teuku Fawzul Akbar, Ivan R. Minev, Jens Pietzsch* and Yixin Zhang*. Cytocompatible, injectable, and electroconductive soft adhesives with hybrid covalent/noncovalent dynamic network. Advanced Science, 6(15), 1802077. (2019). (第一作者, IF 17.521，分区: I区)

[39] Yong Xu, Michelle Patino Gaillez, Rebecca Rothe, Sandra Hauser, Dagmar Voigt, Jens Pietzsch*, Yixin Zhang*. Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications. Advanced Healthcare Materials, 10(11), 2100012. (2021). (第一作者, IF 11.092，分区: I区)

[40] Rebecca Rothe#, Yong Xu#, Alvin Kuriakose Thomas, Sebastian Meister, Yixin Zhang, Jens Pietzsch, Sandra Hauser. A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration. Biomaterials, 269, 120637. (2021). (共同第一作者, IF 15.304，分区: I区)

[41] Yong Xu, Meiying Cui, Panagiotis A. Patsis, Markus Günther, Xuegeng Yang, Kerstin Eckert, and Yixin Zhang*. Reversibly assembled electroconductive hydrogel via a host–guest interaction for 3D cell culture. ACS applied materials & interfaces, 11(8), 7715-7724. (2019). (第一作者, IF 10.383，分区: II区)

[42] Yong Xu, Xuegeng Yang, Alvin Kuriakose Thomas, Panagiotis A. Patsis, Thomas Kurth, Martin Kräter, Kerstin Eckert, Martin Bornhäuser, and Yixin Zhang. Noncovalently Assembled Electroconductive Hydrogel. ACS applied materials & interfaces, 10(17), 14418-14425. (2018). (第一作者, IF 10.383，分区: II区)

授权发明专利

1. Zhang YX, Xu Y, Thomas A K. Non-covalently Assembled Conductive Hydrogel with Modular Structural Motif, Dynamic Network and Seamless Interface with cells. PCT国际专利 (授权号:EP3395327B1&US11166907B2) 欧盟和美国已授权

2. 龚逸鸿; 徐勇; 张栩杰; 何帆; 李燕; 蒋庆 ; 一种静电纺丝纳米纤维-细胞外基质复合材料及其制备方法和应用, 2016-4-20, 中国, ZL201410116021.X 已授权

3. 龚逸鸿; 徐勇; 何帆; 李燕; 蒋庆 ; 一种组织工程天然凝胶支架材料及其制备方法和应用, 2015-5-20, 中国, ZL201310494942.5 已授权

4. 徐勇（第一发明人） 一种羊脊柱髓核胶原蛋白及其提取方法，2024-03-19，中国，ZL 202310989039.X已授权

5. 徐勇（第一发明人） 一种羊脊柱纤维环胶原蛋白及其提取方法和应用，2024-03-19，中国，ZL202310985391.6已授权

6. 徐勇 （第一发明人）一种水凝胶-静电纺丝膜双层混合支架的制备方法,2024-10-28,中国， CN202410799045.3已授权

7. 徐勇 （第一发明人）一种细胞外基质水凝胶微球的制备方法, 2024-09-23,中国， CN118356529A已授权

8. 徐勇 （第一发明人）一种自组装生物玻璃水凝胶、其制备方法及应用，2025-4-18， 中国，ZL 2022 1 1674655.8 已授权

9. 徐勇 （第一发明人）一种墨鱼汁水凝胶微球及其制备方法和应用，2025-03-30. ZL202411857114.8

10. Yong XU. EXTRACELLULAR MATRIX HYDROGEL MICROSPHERE,AND PREPARATION METHOD AND APPLICATION. PCT国际专利 (授权号: us12447234b1) 美国已授权

指导本科生参加竞赛项目获奖

课程教学及招生信息：

本课题组热忱欢迎有志从事科研工作的本科/硕士/研究生以及博士后到课题组学习工作。欢迎具有化学、生物和医学背景的同学加入。如有兴趣，请联系yxu1615 @suda.edu.cn诚挚欢迎各位加入我们的课题组！