徐勇
邮箱地址：yxu1615@suda.edu.cn
联系方式： 15962590786
获得荣誉：
国家级青年人才项目-海外优青
江苏特聘教授，苏州市姑苏领军人才，江苏省科技副总
苏州大学东吴特聘教授-精英人才
苏州工业园区生物医药创新园区博士后导师
苏州大学拔尖人才 东吴特聘教授 骨科研究所特聘教授，PI和博士生导师
学习经历：
2008年09月-2012年06月 中国 本科 南通大学 生物技术
2012年07月-2014年07月 中国 硕士 中山大学 生物医学工程
2014年10月-2019年10月 德国 博士 德累斯顿工业大学 骨医用材料与骨组织工程
工作经历：
2019年5月-2022年7月 德国 德累斯顿工业大学 博士后
2022年7月-至今 中国 苏州大学 教授
研究方向：
骨外科学 再生医学 骨疾病与诊疗一体 器官组织修复 3D生物打印 药物高通量筛选 生物医用水凝胶 转化医学 医用器械材料科
个人介绍：
2014-2022年在德国精英大学-德累斯顿工业大学获得博士学位，在德国一流的生物医学与生物医用高分子材料研究团队完成博士后研究工作，师从欧洲知名生物材料专家Yixin Zhang教授和德国工程院院士Carsten Werner教授。近些年来，在紧紧围绕“骨疾病治疗机制探索- ECM微环境调控-骨组织修复应用”这个关键科学问题开展研究工作。以第一作者和通讯作者在国际一流SCI 期刊上发表研究论文30篇 近三年第一作者代表作例如: Nature Communications、 Advanced Science、Biomaterials、Journal of Controlled Release、Journal of Orthopaedic Translation、 Acta Biomaterialia、 Journal of Nanobiotechnology、Composites Part B：Engineering、Small、Chemical Engineering Journal、Materials Today Bio。2022年7月回国后主持国家自然科学基金和江苏省自然科学基金，国家级以及江苏省，苏州市人才项目。作为项目骨干参与了德国联邦教育与研究部重点项目两项 (BMBF: Biolithomorphie，200万欧元; BMBF: OptiZeD, 200万欧元)。授权国内专利10项，美国和欧洲国际专利2项。以上研究成果也进行了产业转化，成功申请到了德国商业部的科研转化孵化基金(EXIST-Forschungstransfer: EFT–denovoMATRIX,资助金额200万欧元),并于2019年在德国注册成立了生物科技公司“denovoMATRIX”(https://www.denovomatrix.com/),目前产品已经落地，为众多医药和干细胞公司提供安全，稳定和高效率的干细胞大规模扩增个定向调控分化的基质表面产品。2023年1月在苏州工业园区生物产业园注册成立了先觉新材料科技有限公司，注册资本1000万人民币，担任共同创始人和技术负责人，专注于创新型生物材料和医疗器械的研发和转化。
科研项目：
1. 姑苏创新创业青年领军人才，2023.7-2026.6 ，主持
2. 国家级青年人才项目-海外优青，2024.1-2026.12，主持
3. 国家自然科学基金青年项目2024.1-2026.12，主持
4. 江苏省双创人才-江苏特聘教授，2024.1-2026.12，主持
5. 江苏省青年基金项目，2023.7-2026.6，主持
6. 企业合作项目，2023.7-2025.6，主持
7. 企业合作项目，2025.3-2026.3，主持
8. 企业合作项目，2025.6-2028.6，主持
代表性论著：
[1] Yong Xu*, Rebecca Rothe, Dagmar Voigt, Ahmed Sayed, Can Huang, Sandra Hauser, Pao-Wan Lee, Meiying Cui, James P. Sáenz, Aldo R. Boccaccini, Kai Zheng*, Jens Pietzsch*, and Yixin Zhang* A self-assembled dynamic extracellular matrix-like hydrogel system with multi-scale structures for cell bioengineering applications. Acta Biomaterialia, (2023). (第一作者&共同通讯作者, IF 10.633，分区: I区)
[2] Yong Xu*, Michelle Patino Gaillez, Kai Zheng, Dagmar Voigt, Meiying Cui, Thomas Kurth, Lingfei Xiao, Rebecca Rothe, Sandra Hauser, Pao-Wan Lee, Robert Wieduwild, Weilin Lin, Martin Bornhäuser, Jens Pietzsch, Aldo R. Boccaccini, and Yixin Zhang*. A Self‐Assembled Matrix System for Cell‐Bioengineering Applications in Different Dimensions, Scales, and Geometries. Small, 2104758. (2022). (第一作者&共同通讯作者, IF15.153，分区: I区)
[3] Yong Xu, Rebecca Rothe, Dagmar Voigt, Sandra Hauser, Meiying Cui, Takuya Miyagawa, Michelle Patino Gaillez , Thomas Kurth , Martin Bornhäuser, Jens Pietzsch* and Yixin Zhang*.Convergent synthesis of diversified reversible network leads to liquid metal-containing conductive hydrogel adhesives. Nature communications, 12(1), 1-19. (2021). (第一作者, IF 17.694，分区: I区)
[4] Yong Xu, Panagiotis A. Patsis, Sandra Hauser, Dagmar Voigt, Rebecca Rothe, Markus Günther, Meiying Cui, Xuegeng Yang, Robert Wieduwild, Kerstin Eckert, Christoph Neinhuis, Teuku Fawzul Akbar, Ivan R. Minev, Jens Pietzsch* and Yixin Zhang*. Cytocompatible, injectable, and electroconductive soft adhesives with hybrid covalent/noncovalent dynamic network. Advanced Science, 6(15), 1802077. (2019). (第一作者, IF 17.521，分区: I区)
[5] Yong Xu, Michelle Patino Gaillez, Rebecca Rothe, Sandra Hauser, Dagmar Voigt, Jens Pietzsch*, Yixin Zhang*. Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications. Advanced Healthcare Materials, 10(11), 2100012. (2021). (第一作者, IF 11.092，分区: I区)
[6] Rebecca Rothe#, Yong Xu#, Alvin Kuriakose Thomas, Sebastian Meister, Yixin Zhang, Jens Pietzsch, Sandra Hauser. A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration. Biomaterials, 269, 120637. (2021). (共同第一作者, IF 15.304，分区: I区)
[7] Yong Xu, Meiying Cui, Panagiotis A. Patsis, Markus Günther, Xuegeng Yang, Kerstin Eckert, and Yixin Zhang*. Reversibly assembled electroconductive hydrogel via a host–guest interaction for 3D cell culture. ACS applied materials & interfaces, 11(8), 7715-7724. (2019). (第一作者, IF 10.383，分区: II区)
[8] Yong Xu, Xuegeng Yang, Alvin Kuriakose Thomas, Panagiotis A. Patsis, Thomas Kurth, Martin Kräter, Kerstin Eckert, Martin Bornhäuser, and Yixin Zhang. Noncovalently Assembled Electroconductive Hydrogel. ACS applied materials & interfaces, 10(17), 14418-14425. (2018). (第一作者, IF 10.383，分区: II区)
2022年7月入职苏州大学后的研究成果：
[9] Can Huang, Lanlan Dong, Baohua Zhao, Yifei Lu, Shurun Huang, Zhiqiang Yuan, Gaoxing Luo*, Yong Xu*, Wei Qian*. Anti-inflammatory hydrogel dressings and skin wound healing. Clinical and Translational Medicine, 12(11), e1094. (2022). (共同通讯作者, IF = 10.6，分区: II区)
[10] X Xia, Y Liu, Y Lu, J Liu, Y Deng, Y Wu, M Hou, F He, H Yang, Y Xu*, Y Zhang*, X Zhu* Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3‐energized And Microenvironment‐Modulated Hydrogel Microspheres to Impede Osteoarthritis. Advanced Healthcare Materials (2023): 2302475 (共同通讯作者, IF = 11.092，分区: I区)
[11] X Hu, Xin Tian, C Yang, F Ling, H Liu, X Zhu, M Pei, H Yang , T Liu, Y Xu*, F He*. Melatonin-loaded self-healing hydrogel targets mitochondrial energy metabolism and promotes annulus fibrosus regeneration. Materials Today Bio (2023): 100811. (共同通讯作者, IF = 8.2，分区: I区)
[12] Can Huang, Lanlan Dong, Baohua Zhao, Shurun Huang, Yifei Lu, Xiaorong Zhang, Xiaohong Hu, Yong Huang, Weifeng He, Yong Xu*, Wei Qian* & Gaoxing Luo*. Tunable Sulfated Alginate-based Hydrogel Platform with enhanced anti-inflammatory and antioxidant capacity for promoting burn wound repair." Journal of Nanobiotechnology 21.1 (2023): 387. (共同通讯作者, IF = 10.2,分区: I区)
[13] Zhangzhe Zhou, Yang Liu, Wenjing Li, Zhijian Zhao, Xiaowei Xia, Junlin Liu, Yaoge Deng, Yubin Wu, Xiangqiang Pan, Fan He, Huilin Yang, Weihong Lu*, Yong Xu*, Xuesong Zhu*. A Self‐Adaptive Biomimetic Periosteum Employing Nitric Oxide Release for Augmenting Angiogenesis in Bone Defect Regeneration[J]. Advanced Healthcare Materials, 2023: 2302153. (共同通讯作者, IF = 10,分区: I区)
[14] H Liu, X Tian, C Jin, Y Li, X Zhu, M Pei, T Liu, H Yang*, Y Xu*, F He* Delivering cells via ECM mimetic hydrogel microspheres for promoting the reconstruction of rat lumbar nucleus pulposus." Chemical Engineering Journal (2024): 150212. (共同通讯作者, IF = 15.1,分区: I区)
[15] J Liu, Z Zhou, M Hou, X Xia, Y Liu, Z Zhao, Y Wu, Y Deng, Y Zhang, F He*, Y Xu*, X Zhu*. Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration[J]. Materials Today Bio, 2024, 25: 100956. (共同通讯作者, IF = 8.2,分区: I区)
[16] Xiaoyang Ge, Chengyue Wang, Guanyu Yang, Dimulati Maimaiti, Mingzhuang Hou, Hao Liu, Huilin Yang, Xi Chen, Yong Xu*, Fan He*. Enhancement of mitochondrial energy metabolism by melatonin promotes vascularized skeletal muscle regeneration in a volumetric muscle loss model[J]. Free Radical Biology and Medicine, 2023. (共同通讯作者, IF =7.4分区: I区)
[17] B Zhang, Z Zhou, Y Zhang, Y Miu, C Jin, W Ding, G Zhao, Yong Xu*. A sugary solution: Harnessing polysaccharide-based materials for osteoporosis treatment. Carbohydrate Polymers (2024): 122549. (共同通讯作者, IF = 10.7分区: I区)
[18] J Chen, X Zhou, Y Li, T Liu, W Ding, F He, Yong Xu*. Transforming Osteoarthritis Treatment: Embracing Hydrogel Microspheres. ACS Materials Letters 6.8 (2024): 3862-3882. (共同通讯作者, IF = 9.6分区: I区)
[19] M Hou, Y Deng, N Lv, Y Wu, Y Zhu, Y Zhang, Y Liu, X Xia, C Yu, J Yu, F He*, Yong Xu*, X Zhu* Cyclic amplification of remodeling bone regeneration process via cerium-energized spinning hydrogel biomembrane for rescuing osteoporotic bone defects. Chemical Engineering Journal 492 (2024): 152262. (共同通讯作者, IF = 15.1,分区: I区)
[20] Rebecca Rothe#, Yong Xu#, Johanna Wodtke, Florian Brandt, Sebastian Meister, Markus Laube, Pier‐Luigi Lollini, Yixin Zhang, Jens Pietzsch, Sandra Hauser. Programmable Release of Chemotherapeutics from Ferrocene‐Based Injectable Hydrogels Slows Melanoma Growth. Advanced Healthcare Materials (2024): 2400265. (共同通讯作者, IF = 10,分区: I区)
[21] Xiaozhen Liu，Zhuozhuo Ren，Xuli Meng* & Yong Xu*. Substrate topography regulates extracellular matrix component secretion by bone marrow-derived mesenchymal stem cells. Journal of Science: Advanced Materials and Devices, 100437. (2022). (通讯作者, IF = 7.382，分区: II区)
[22] Wei He, Xin Tian, Quan Zhou, Jiaheng Lv, Yangfeng Li, Chenyang Jin, Hao Liu, Huiling Yang, Yong Xu*, Fan He* & Tao Liu* Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells. J Nanobiotechnol 22, 634 (2024). (共同通讯作者, IF = 10.6，分区: I区)
[23] Dimulati Maimaiti, Xiaoyang Ge, Chengyue Wang, Jinuo Liu, Guanyu Yang, Dachuan Zhang, Yong Xu*, Fan He*, Xi Chen*. Extracellular matrix-mimicking cryogels composed of methacrylated fucoidan enhance vascularized skeletal muscle regeneration following volumetric muscle loss. International Journal of Biological Macromolecules 283 (2024): 137122. (共同通讯作者, IF = 7.7，分区: I区)
[24]X Wang, Y Huang, Y Yang, X Tian, Y Jin, W Jiang, H He*, Y Xu*, Y Liu*. Polysaccharide-Based Biomaterials for Regenerative Therapy in Intervertebral Disc Degeneration. Materials Today Bio (2024): 101395. (共同通讯作者, IF = 8.7，分区: I区)
[25] Zhiyang Ren, Shuhan Tang, Jia Wang, Shuqing Lv, Kai Zheng*, Yong Xu*, Ke Li*. Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations. Biomaterials Research 29 (2025): 0134. (共同通讯作者, IF = 8.1，分区: I区)
[26] Q Hou, X He, M Guo, X Li, Z Zhang, X Xu, Y Xu*, Q Shi*, Y Han* . Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding." Journal of Nanobiotechnology 23.1 (2025): 1-19. (共同通讯作者, IF = 10.6，分区: I区)
[27] X Zhou, X Tian, J Chen, Y Li, N Lv, H Liu, T Liu, H Yang, X Chen*, Y Xu*, F He*. Youthful Stem Cell Microenvironments: Rejuvenating Aged Bone Repair Through Mitochondrial Homeostasis Remodeling. Advanced Science (2025): 2409644. (共同通讯作者, IF = 14.44，分区: I区)
[28] S Zhao, X Hu, Y Zhao, Y Zhang, Y Jin, F Hua*, Y Xu*, W Ding*. Hydrogel-based therapies for diabetic foot ulcers: recent developments and clinical implications." Burns & Trauma 13 (2025): tkae084. (共同通讯作者, IF =6.3，分区: I区)
[29] Can Huang, Yijie Liu, Baohua Zhao, Mengjun He, Shurun Huang, Lanlan Dong, Yifei Lu, Guangyun Hu, Xiaoqing Zhou, Yong Xu*, Wei Qian*, Gaoxing Luo*. Dual-Response Hydrogel System Coordinating Immunomodulation and Tissue Repair for Promoting Infected Burn Wound Healing. ACS Materials Letters, 2025, 7: 489-499. (共同通讯作者, IF =9.9，分区: I区)
[30] Junqi Dai, Li Ni , Chenyang Jin , Xin Tian , Yujie Shen , Yan Miao, Yong Xu* , Fan He* , Huilin Yang* Esterase-responsive kartogenin composite hydrogel microspheres boost nucleus pulposus regeneration in intervertebral disc degeneration. Acta Biomaterialia 2025 (共同通讯作者, IF =9.4，分区: I区)
[31]Yilin Yang, Jiangbo Guo, Haifei Cao, Xin Tian, Hao Shen, Junjie Niu, Huilin Yang, Qin Shi, Yong Xu*. "Seeds-and-Soil Inspired Hydrogel Microspheres: A Dual-Action Antioxidant and Cellular Therapy for Reversing Intervertebral Disc Degeneration." Biomaterials (2025): 123326. (共同通讯作者, IF =12，分区: I区)
[32]Xin Tian, Yan Miao, Hao Liu, Chenyang Jin, Tao Liu , Wenge Ding , Fan He, Yong Xu* "Bioinspired hydrogel microspheres enhance nucleus pulposus regeneration through N-cadherin interaction with extracellular matrix mimicry." Journal of Controlled Release (2025): 113771. (共同通讯作者, IF =10.8，分区: I区)
[33]XinTian,ChenyangJin,YanMiao,HaoLiu,XiChen,Wenge Ding*, Fan He*, Yong Xu* Dynamic Dual-Network Hydrogel Microspheres for Enhanced Nucleus Pulposus Regeneration via Extracellular Matrix Mimicry. Composites Part B: Engineering (2025) .112715.(末位通讯作者, IF =12.4，分区: I区)
[34] Feng Ling , Xiayu Hu, Yujie Shen, Xi Chen, Zonglai Qian, Hao Liu*, Yong Xu*, Fan He* Polysaccharide hydrogel-reinforced nanofibrous composite promotes annulus fibrosus regeneration by regulating mitochondrial antioxidant and metabolic functions. Chemical Engineering Journal (2025),164696. (共同通讯作者, IF =13.2，分区: I区)
[35] Xu He, Xingzhi Liu, Xinyi Cheng, Can Zhu, Yida Chen, Yi Wang, Yun Zhou, Hao Shen, Huilin Yang, Yong Xu*, Qin Shi*, Junjie Niu* Bionic bearing-inspired lubricating microspheres with immunomodulatory effects for osteoarthritis therapy. Journal of Nanobiotechnology 23, 457 (2025). (共同通讯作者, IF = 12.6，分区: I区)
[36] Xiaoyang Ge, Yesheng Jin, Jingyuan He, Zhihao Jia*, Ying Liu*, Yong Xu* Extracellular matrix in skeletal muscle injury and atrophy: mechanisms and therapeutic implications. Journal of Orthopaedic Translation (2025),404-418,52. (末位通讯作者, IF = 7.8，分区: I区)
授权专利：
1. Zhang YX, Xu Y, Thomas A K. Non-covalently Assembled Conductive Hydrogel with Modular Structural Motif, Dynamic Network and Seamless Interface with cells. PCT国际专利 (授权号:EP3395327B1&US11166907B2) 欧盟和美国已授权
2. 龚逸鸿; 徐勇; 张栩杰; 何帆; 李燕; 蒋庆， 一种静电纺丝纳米纤维-细胞外基质复合材料及其制备方法和应用, 2016-4-20, 中国, ZL201410116021.X 已授权
3. 龚逸鸿; 徐勇; 何帆; 李燕; 蒋庆 ， 一种组织工程天然凝胶支架材料及其制备方法和应用, 2015-5-20, 中国, ZL201310494942.5 已授权
4. 徐勇; 张丽蓉；马一鸣，一种羊脊柱髓核胶原蛋白及其提取方法，2024-03-19，中国，ZL 202310989039.X已授权
5. 徐勇; 张丽蓉；马一鸣，一种羊脊柱纤维环胶原蛋白及其提取方法和应用，2024-03-19，中国，ZL202310985391.6已授权
6. 徐勇 （第一发明人），一种水凝胶-静电纺丝膜双层混合支架的制备方法，2024-10-28，中国， CN202410799045.3已授权
7. 徐勇 （第一发明人），一种细胞外基质水凝胶微球的制备方法，2024-09-23，中国， CN118356529A已授权
8. 徐勇 （第一发明人）一种自组装生物玻璃水凝胶、其制备方法及应用，2025-4-18，中国，ZL 2022 1 1674655.8 已授权
9. 徐勇 （第一发明人）一种墨鱼汁水凝胶微球及其制备方法和应用，2025-03-30，中国，ZL202411857114.8已授权
课程教学及招生信息：
本课题组热忱欢迎有志从事科研工作的本科/硕士/研究生以及博士后到课题组学习工作。欢迎具有化学、生物和医学背景的同学加入。如有兴趣，请联系yxu1615 @suda.edu.cn诚挚欢迎各位加入我们的课题组！
