基本信息
姓名：秦昕
学院/部门：苏州大学骨科研究所
职称：副教授
学历/学位：博士
导师类别：硕士生导师（学术型）
招生专业：生物学
邮箱：xqin@suda.edu.cn
办公地址：苏州市姑苏区干将东路178号苏州大学北校区机物楼
个人简介
2009年于吉林师范大学获学士学位，2019年于日本国立长崎大学获博士学位。2019年至2022年间在长崎大学任博士后（JSPS fellow）。2022年入职苏州大学骨科研究所，现任副教授，硕士生导师。
长期从事骨生物学领域的研究，已在骨科权威期刊Journal of Bone and Mineral Research，Journal of Orthopaedic Translation；遗传学经典期刊PLoS Genetics，Human Molecular Genetics；Frontiers in Cell and Developmental Biology；International Journal of Molecular Sciences等国际期刊发表论文18篇，Google scholar引用1100余次。主持苏州市科技攻关面上项目、苏州大学科研启动经费、苏州医学院交叉种子基金项目。担任Frontiers in Cell and Developmental Biology 杂志Review editor。
具体研究方向
课题组利用基因敲除、敲入、转基因小鼠等模型，结合组织学、细胞生物学和分子生物学等实验技术手段，揭示骨骼发育过程的分子调控机制。研究重点聚焦于成骨细胞和软骨细胞增殖及分化过程中的分子调控机制，并致力于阐明骨质疏松症和骨关节炎等骨骼疾病的致病机制。
代表论文 (#共同第一作者，*共同通讯作者)
(1) Qing Jiang#, Manyu Zhang#, Haoyunyan Jin, Ziheng Zhang, Chiharu Sakane, Yuki Matsuo, Simeng Lai, Wen Zhang, Huilin Yang, Toshihisa Komori*, Xin Qin*. Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development. Frontiers in Cell and Developmental Biology. 2026.14:1770176. (IF:5.2, Q1)
(2) Xin Qin#, Qing Jiang#, Longfei Wu, Suemi Yabuta, Chiharu Sakane, Yuki Matsuo, Ziheng Zhang, Hisato Komori, Manyu Zhang, Kosei Ito, Toshihisa Komori. Runx2 in the Perichondrial Osteoblasts Enhances Terminal Differentiation of Chondrocytes Through Nell1 Induction. International Journal of Molecular Sciences. 2026, 27, 1266. (IF:5.6, Q1)
(3) Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin*, Toshihisa Komori*. Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation. Journal of Orthopaedic Translation. 2024, 47, 161–175 (IF:9.8, Q1, Top)
(4) Wenguang Liu, Manyu Zhang, Lili Wu, Toshihisa Komori, Haoyunyan Jin, Huilin Yang, Qing Jiang*, Xin Qin*. Entinostat treatment causes hypophosphatemia and hypocalcemia by increasing Fgf23 in mice. Biochemical and Biophysical Research Communications. 2024, 739:150970. (IF:2.5, Q3)
(5) Qing Jiang#, Xin Qin#, Takeshi Moriishi, Shinichi Katsumata, Hiroshi Matsuzaki, Ryo Fukuyama, Toshihiro Miyazaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, Hironori Hojo, Shinsuke Ohba, Toshihisa Komori. Runx2 regulates Galnt3 and Fgf23 expressions and Galnt3 decelerates osteoid mineralization by stabilizing Fgf23. International Journal of Molecular Sciences, 2024, 25(2275). (IF:5.6, Q1)
(6) Qing Jiang#, Xin Qin#, Kenichi Nagano, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Toshihisa Komori. Different requirements of CBFB and RUNX2 in skeletal development among calvaria, limbs, vertebrae and ribs. International Journal of Molecular Sciences, 2022, 23(13299). (IF:5.6, Q1)
(7) Xin Qin#,Qing Jiang#, Hisato Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori. Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice. Journal of Bone and Mineral Research, 2021, 36(10): 2081-2095. (IF:6.5, Q1, Top)
(8) Qing Jiang#, Xin Qin#, Carolina Andrea Yoshida, Hisato Komori, Kei Yamana, Shinsuke Ohba, Hironori Hojo, Brad St. Croix, Viviane K. S. Kawata-Matsuura, Toshihisa Komori. Antxr1, which is a target of Runx2, regulates chondrocyte proliferation and apoptosis. International Journal of Molecular Sciences, 2020, 21(2425). (IF:5.6, Q1)
(9) Xin Qin#, Qing Jiang#, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genetics, 2020,16(11) e1009169. (IF:3.9, Q1, Top)
(10) Xin Qin, Qing Jiang, Toshihiro Miyazaki and Toshihisa Komori. Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells. Human Molecular Genetics. 2019, 28(6): 896-911. (IF:3.1, Q2, Top)
(11) Qing Jiang, Xin Qin, Tetsuya Kawane, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Shin-ichi Izumi, Toshihisa Komori. Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development. Journal of Bone and Mineral Research, 2016, 31(7): 1391-1404. (IF:6.5, Q1, Top)
(12) Xin Qin, Qing Jiang, Yuki Matsuo, Tetsuya Kawane, Hisato Komori, Takeshi Moriishi, Ichiro Taniuchi, Kosei Ito, Yosuke Kawai, Satoshi Rokutanda, Shinichi Izumi, and Toshihisa Komori. Cbfb regulates bone development by stabilizing Runx family proteins. Journal of Bone and Mineral Research, 2015, 30(4): 706-714. (IF:6.5, Q1, Top)
