基本信息：
秦昕，苏州大学苏州医学院骨科研究所特聘副教授，硕士研究生导师。国际华人骨研学会（ICMRS）会员，日本学术振兴会外国人特别研究员（JSPS fellow，2017–2019博士研究员，2020–2022博士后研究员），日本国立长崎大学客座研究员。2022年7月加入骨科研究所，组建骨骼分子生物学实验室。课题组利用基因敲除、敲入、转基因小鼠等模型，结合组织学、细胞生物学和分子生物学等实验技术手段，揭示骨骼发育过程的分子调控机制。主要针对成骨细胞和软骨细胞增殖以及分化过程的分子调控机制，以及阐明骨质疏松症和骨关节炎等疾病的致病机制。
研究成果发表于骨科权威期刊Journal of Bone and Mineral Research，Journal of Orthopaedic Translation；遗传学经典期刊PLoS Genetics，Human Molecular Genetics等SCI杂志，总计17篇，Google scholar引用大于1000次。
期待感兴趣的同学加入我们团队！
联系方式：
联系电话：13584890432
邮 箱：qinxin_19861009@163.com，xqin@suda.edu.cn
现地址：苏州大学北校区机物楼217-1办公室。
代表论文：(#共同第一作者，*共同通讯作者)
（1）Qing Jiang#, Manyu Zhang#, Haoyunyan Jin, Ziheng Zhang, Chiharu Sakane, Yuki Matsuo, Simeng Lai, Wen Zhang, Huilin Yang, Toshihisa Komori*, Xin Qin*. Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development. Frontiers in Cell and Developmental Biology. 2026, accepted. (IF：4.3，Q1)
（2）Xin Qin#, Qing Jiang#, Longfei Wu, Suemi Yabuta, Chiharu Sakane, Yuki Matsuo, Ziheng Zhang, Hisato Komori, Manyu Zhang, Kosei Ito, Toshihisa Komori. Runx2 in the Perichondrial Osteoblasts Enhances Terminal Differentiation of Chondrocytes Through Nell1 Induction. International Journal of Molecular Sciences. 2026, 27, 1266. (IF：4.9，Q1)
（3）Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin*, Toshihisa Komori*. Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation. Journal of Orthopaedic Translation. 2024, 47, 161–175 (IF：7.8，Q1，Top)
（4）Wenguang Liu, Manyu Zhang, Lili Wu, Toshihisa Komori, Haoyunyan Jin, Huilin Yang, Qing Jiang*, Xin Qin*.Entinostat treatment causes hypophosphatemia and hypocalcemia by increasing Fgf23 in mice. Biochemical and Biophysical Research Communications. 2024, 739:150970. (IF：2.2，Q3)
（5）Qing Jiang#, Xin Qin#, Takeshi Moriishi, Shinichi Katsumata, Hiroshi Matsuzaki, Ryo Fukuyama, Toshihiro Miyazaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, Hironori Hojo, Shinsuke Ohba, Toshihisa Komori. Runx2 regulates Galnt3 and Fgf23 expressions and Galnt3 decelerates osteoid mineralization by stabilizing Fgf23. International Journal of Molecular Sciences, 2024, 25(2275). (IF：4.9，Q1)
（6）Qing Jiang#, Xin Qin#, Kenichi Nagano, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Toshihisa Komori. Different requirements of CBFB and RUNX2 in skeletal development among calvaria, limbs, vertebrae and ribs. International Journal of Molecular Sciences, 2022, 23(13299). (IF：4.9，Q1)
（7）Xin Qin#,Qing Jiang#, Hisato Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori. Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice. Journal of Bone and Mineral Research, 2021, 36(10): 2081-2095. (IF：5.9，Q1，Top)
（8）Qing Jiang#, Xin Qin#, Carolina Andrea Yoshida, Hisato Komori, Kei Yamana, Shinsuke Ohba, Hironori Hojo, Brad St. Croix, Viviane K. S. Kawata-Matsuura, Toshihisa Komori. Antxr1, which is a target of Runx2, regulates chondrocyte proliferation and apoptosis. International Journal of Molecular Sciences, 2020, 21(2425). (IF：4.9，Q1)
（9）Xin Qin#, Qing Jiang#, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genetics, 2020,16(11) e1009169. (IF：3.7，Q2，Top)
（10）Xin Qin, Qing Jiang, Toshihiro Miyazaki and Toshihisa Komori. Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells. Human Molecular Genetics. 2019, 28(6): 896-911. (IF：3.2，Q2，Top )
（11）Qing Jiang, Xin Qin, Tetsuya Kawane, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Shin-ichi Izumi, Toshihisa Komori. Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development. Journal of Bone and Mineral Research, 2016, 31(7): 1391-1404. (IF：5.9，Q1，Top)
（12）Xin Qin, Qing Jiang, Yuki Matsuo, Tetsuya Kawane, Hisato Komori, Takeshi Moriishi, Ichiro Taniuchi, Kosei Ito, Yosuke Kawai, Satoshi Rokutanda, Shinichi Izumi, and Toshihisa Komori. Cbfb regulates bone development by stabilizing Runx family proteins. Journal of Bone and Mineral Research, 2015, 30(4): 706-714. (IF：5.9，Q1，Top)
