基本信息
姓名：姜晴
学院/部门：苏州大学骨科研究所
职称：副教授
学历/学位：博士
导师类别：硕士生导师（学术型）
招生专业：生物学
邮箱：qjiang1006@suda.edu.cn
办公地址：苏州市姑苏区干将东路178号苏州大学北校区机物楼
个人简介
2009年于吉林师范大学获学士学位，2011年于东北师范大学获硕士学位，2016年于日本国立长崎大学获博士学位。2016年至2022年间在长崎大学任助理教授。2022年入职苏州大学骨科研究所，现任副教授，硕士生导师。
长期从事骨骼发育相关基因表达调控的研究，已在已在骨科权威期刊Journal of Bone and Mineral Research，Journal of Orthopaedic Translation；遗传学经典期刊PLoS Genetics，Human Molecular Genetics；Frontiers in Cell and Developmental Biology；International Journal of Molecular Sciences等国际期刊发表论文18篇，Google scholar引用1000余次。主持江苏省自然科学基因、苏州大学科研启动经费、苏州医学院交叉种子基金项目。担任Frontiers in Cell and Developmental Biology 杂志Review editor。
具体研究方向
课题组使用基因敲除、敲入、转基因小鼠等模型，利用分子生物学、细胞生物学等技术手段，旨在揭示骨骼发育过程的分子调控机制。通过阐明骨的形成机制以及关节软骨被破坏的机制为基础，进行骨质疏松症和骨关节炎治疗药物的开发。目前主要研究方向是骨骼发育过程中重要基因的增强子开发及应用。期待感兴趣的同学加入我们团队！
代表论文 (#共同第一作者，*共同通讯作者)
(1) Qing Jiang#, Manyu Zhang#, Haoyunyan Jin, Ziheng Zhang, Chiharu Sakane, Yuki Matsuo, Simeng Lai, Wen Zhang, Huilin Yang, Toshihisa Komori*, Xin Qin*. Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development. Frontiers in Cell and Developmental Biology. 2026.14:1770176. (IF:5.2, JCR Q1, 中科院二区)
(2) Xin Qin#, Qing Jiang#, Longfei Wu, Suemi Yabuta, Chiharu Sakane, Yuki Matsuo, Ziheng Zhang, Hisato Komori, Manyu Zhang, Kosei Ito, Toshihisa Komori. Runx2 in the Perichondrial Osteoblasts Enhances Terminal Differentiation of Chondrocytes Through Nell1 Induction. International Journal of Molecular Sciences. 2026, 27, 1266. (IF:5.6, JCR Q1, 中科院三区, #共一）
(3) Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin*, Toshihisa Komori*. Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation. Journal of Orthopaedic Translation. 2024, 47, 161–175 (IF:9.8, JCR Q1, 中科院一区Top）
(4) Wenguang Liu, Manyu Zhang, Lili Wu, Toshihisa Komori, Haoyunyan Jin, Huilin Yang, Qing Jiang*, Xin Qin*. Entinostat treatment causes hypophosphatemia and hypocalcemia by increasing Fgf23 in mice. Biochemical and Biophysical Research Communications. 2024, 739:150970. (IF:2.5, JCR Q3, 中科院三区, *共通讯）
(5) Qing Jiang#, Xin Qin#, Takeshi Moriishi, Shinichi Katsumata, Hiroshi Matsuzaki, Ryo Fukuyama, Toshihiro Miyazaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, Hironori Hojo, Shinsuke Ohba, Toshihisa Komori. Runx2 regulates Galnt3 and Fgf23 expressions and Galnt3 decelerates osteoid mineralization by stabilizing Fgf23. International Journal of Molecular Sciences, 2024, 25(2275). (IF:5.6, JCR Q1, 中科院三区）
(6) Qing Jiang#, Xin Qin#, Kenichi Nagano, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Toshihisa Komori. Different requirements of CBFB and RUNX2 in skeletal development among calvaria, limbs, vertebrae and ribs. International Journal of Molecular Sciences, 2022, 23(13299). (IF:5.6, JCR Q1, 中科院三区）
(7) Xin Qin#, Qing Jiang#, Hisato Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori. Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice. Journal of Bone and Mineral Research, 2021, 36(10): 2081-2095. (IF:6.5, JCR Q1, 中科院一区Top, #共一）
(8) Qing Jiang#, Xin Qin#, Carolina Andrea Yoshida, Hisato Komori, Kei Yamana, Shinsuke Ohba, Hironori Hojo, Brad St. Croix, Viviane K. S. Kawata-Matsuura, Toshihisa Komori. Antxr1, which is a target of Runx2, regulates chondrocyte proliferation and apoptosis. International Journal of Molecular Sciences, 2020, 21(2425). (IF:5.6, JCR Q1, 中科院三区）
(9) Xin Qin#, Qing Jiang#, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genetics, 2020,16(11) e1009169. (IF:3.9, JCR Q2, 中科院二区Top, #共一）
(10) Xin Qin, Qing Jiang, Toshihiro Miyazaki and Toshihisa Komori. Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells. Human Molecular Genetics. 2019, 28(6): 896-911. (IF:3.1, JCR Q2, 中科院二区, Top)
(11) Qing Jiang, Xin Qin, Tetsuya Kawane, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Shin-ichi Izumi, Toshihisa Komori. Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development. Journal of Bone and Mineral Research, 2016, 31(7): 1391-1404. (IF:6.5, JCR Q1, 中科院一区, Top）
(12) Xin Qin, Qing Jiang, Yuki Matsuo, Tetsuya Kawane, Hisato Komori, Takeshi Moriishi, Ichiro Taniuchi, Kosei Ito, Yosuke Kawai, Satoshi Rokutanda, Shinichi Izumi, and Toshihisa Komori. Cbfb regulates bone development by stabilizing Runx family proteins. Journal of Bone and Mineral Research, 2015, 30(4): 706-714. (IF:6.5, JCR Q1, 中科院一区, Top）
