基本信息：
姜晴，博士，苏州大学苏州医学院骨科研究所特聘副教授（2022-），硕士研究生导师。日本文部省国费博士留学生（2011-2016），日本国立长崎大学助理教授（2016-2022），长崎大学客座研究员（2022-）。国际华人骨研学会（ICMRS）会员（2022-），中国细胞生物学学会会员（2022-）、日本骨代谢协会（JSBMR）会员（2017-）。多年来从事骨骼发育相关的分子调控机制等基础研究，主要围绕骨骼发育关键转录因子Runx2开展的系列基础生物学研究。
姜晴老师的成果发表于骨科高水平期刊及经典遗传学杂志Journal of Bone and Mineral Research, Journal of Orthopaedic Translation, PLoS Genetics等 SCI 杂志，累计被引用 800 余次。2022年7月回国，组建骨骼系统分子生物学实验室，主持江苏省自然科学基金青年项目、苏州市医学应用基础研究、苏州大学人才引进科研启动项目、苏州医学院基础前沿创新交叉科研专项项目等。
课题组使用基因敲除、敲入、转基因小鼠等模型，利用分子生物学、细胞生物学等技术手段，旨在揭示骨骼发育过程的分子调控机制。通过阐明骨的形成机制以及关节软骨被破坏的机制为基础，进行骨质疏松症和骨关节炎治疗药物的开发。目前主要研究方向是骨骼发育过程中重要基因的增强子开发及应用。期待感兴趣的同学加入我们团队！
联系方式：
联系电话：13915572219
邮 箱：jiangqing19861006@163.com，qjiang1006@suda.edu.cn
现地址：苏州大学北校区机物楼217-1办公室。
代表论文：
（1）Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin*, Toshihisa Komori*. Knockdown or deletion of Sp7 in osteoblasts results in an increase of trabecular bone through the accumulation of immature osteoblasts and porous cortical bone due to osteocyte apoptosis. Journal of Orthopaedic Translation, 2024,47:161-175.（IF:5.9，JCR Q1，中科院一区Top）
（2）Qing Jiang#, Xin Qin#, Takeshi Moriishi, Shinichi Katsumata, Hiroshi Matsuzaki, Ryo Fukuyama, Toshihiro Miyazaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, Hironori Hojo, Shinsuke Ohba, Toshihisa Komori. Runx2 regulates Galnt3 and Fgf23 expressions and Galnt3 decelerates osteoid mineralization by stabilizing Fgf23. International Journal of Molecular Sciences, 2024,25(2275).（IF:4.9，JCR Q1，中科院二区）
（3）Wenguang Liu, Manyu Zhang, Lili Wu, Toshihisa Komori, Haoyunyan Jin, Huilin Yang, Qing Jiang*, Xin Qin*. Entinostat treatment causes hypophosphatemia and hypocalcemia by increasing Fgf23 in mice. Biochemical and Biophysical Research Communications. 2024,739:150970.（IF:2.5，JCR Q2，中科院三区，*共通讯）
（4）Qing Jiang#, Xin Qin#, Kenichi Nagano, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Toshihisa Komori. Different requirements of CBFB and RUNX2 in skeletal development among calvaria, limbs, vertebrae and ribs. International Journal of Molecular Sciences, 2022,23(13299).（IF:4.9，JCR Q1，中科院二区）
（5）Xin Qin#,Qing Jiang#, Hisato Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori. Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice. Journal of Bone and Mineral Research, 2021, 36(10): 2081-2095.（IF:5.1，JCR Q1，中科院一区Top，#共一）
（6）Qing Jiang#, Xin Qin#, Carolina Andrea Yoshida, Hisato Komori, Kei Yamana, Shinsuke Ohba, Hironori Hojo, Brad St. Croix, Viviane K. S. Kawata-Matsuura, Toshihisa Komori. Antxr1, which is a target of Runx2, regulates chondrocyte proliferation and apoptosis. International Journal of Molecular Sciences, 2020, 21(2425).（IF:4.9，JCR Q1，中科院二区）
（7）Xin Qin#, Qing Jiang#, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genetics, 2020,16(11) e1009169.（IF:4.0，JCR Q1，中科院二区Top，#共一）
（8）Qing Jiang, Xin Qin, Tetsuya Kawane, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Shin-ichi Izumi, Toshihisa Komori. Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development. Journal of Bone and Mineral Research, 2016, 31(7): 1391-1404.（IF:5.1，JCR Q1，中科院一区Top）
其他论文：
（1）Yuki Matsuo, Xin Qin, Takeshi Moriishi, Viviane K. S. Kawata-Matsuura, Hisato Komori, Chiharu Sakane, Suemi Yabuta, Qing Jiang, Hitomi Kaneko, Kosei Ito, Mayo Shigeta, Takaya Abe and Toshihisa Komori. An osteoblast-specific enhancer and a subenhancer cooperatively regulate Runx2 expression in chondrocytes. International Journal of Molecular Sciences, 2025, 3423641.
（2）Xin Qin, Qing Jiang, Toshihiro Miyazaki and Toshihisa Komori. Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells. Human Molecular Genetics, 2019, 28(6): 896-911.
（3）Viviane K. S. Kawata Matsuura, Carolina Andrea Yoshida, Hisato Komori, Chiharu Sakane, Kei Yamana, Qing Jiang and Toshihisa Komori. Expression of a constitutively active form of Hck in chondrocytes activates Wnt and Hedgehog signaling pathways, and induces chondrocyte proliferation in mice. International Journal of Molecular Sciences, 2020, 21(2682).
（4）Tetsuya Kawane, Xin Qin, Qing Jiang, Toshihiro Miyazaki, Hisato Komori, Carolina Andrea Yoshida, Viviane Keiko dos Santos Matsuura-Kawata, Chiharu Sakane, Yuki Matsuo, Kazuhiro Nagai, Takafumi Maeno, Yuki Date, Riko Nishimura, Toshihisa Komori. Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3. Scientific Reports. 2018, 8(13551).
（5）Xin Qin, Qing Jiang, Yuki Matsuo, Tetsuya Kawane, Hisato Komori, Takeshi Moriishi, Ichiro Taniuchi, Kosei Ito, Yosuke Kawai, Satoshi Rokutanda, Shinichi Izumi, and Toshihisa Komori. Cbfb regulates bone development by stabilizing Runx family proteins. Journal of Bone and Mineral Research, 2015, 30(4): 706-714.
（6）Ping Mu, Vishwa Deepak, Liheng Kang, Qing Jiang, Rong Liu, Lingyi Meng, Zhongli Zhang, Xianlu Zeng, and Wenguang Liu. Ratjadone C-mediated nuclear accumulation of HDAC4: Implications on Runx2-Induced osteoblast differentiation of C3H10T1/2 mesenchymal stem cells. Zeitschrift Fur Naturforschung. 2014, 69c, 471-478.
（7）Tetsuya Kawane, Hisato Komori, Wenguang Liu, Takeshi Moriishi, Toshihiro Miyazaki, Masako Mori, Yuki Matsuo, Yoshio Takada, Shinichi Izumi, Qing Jiang, Riko Nishimura, Yosuke Kawai, and Toshihisa Komori.Dlx5 and Mef2 regulate a novel Runx2 enhancer for osteoblast-specific expression. Journal of Bone and Mineral Research, 2014, 29(9): 1960-1969.
（8）Zhongli Zhang, Vishwa Deepak, Lingyi Meng, Linghui Wang, Yushan Li, Qing Jiang, Xianlu Zeng, Wenguang Liu. Analysis of HDAC1-mediated regulation of Runx2-induced osteopontin gene expression in C3h10t1/2 cells. Biotechnology Letters, 2012, 34: 197-203.
