基本信息
姓名：杨晨
学院/部门：苏州大学骨科研究所
职称/职务：青年特聘教授
学历/学位：博士
邮箱：cryangchen@suda.edu.cn
办公地址：江苏省苏州市姑苏区干将东路178号苏州大学北校区机物楼
个人简介
杨晨，苏州大学骨科研究所副教授。2018年获中国科学院上海硅酸盐研究所材料学博士学位，先后在深圳大学、中国科学院大学温州研究院从事博士后及副研究员工作。2025年加入苏州大学骨科研究所。研究方向聚焦生物活性材料与难愈性组织损伤修复。目前以第一/通讯作者（含共同）身份在Advanced Materials、Advanced Functional Materials、Advanced Science、Biomaterials、Bioactive Materials、Exploration、Science Bulletin等国际专业期刊上发表SCI论文近50篇。已申请国家发明专利22项（其中已授权14项）。主持国家自然科学基金面上项目（2项）/青年基金、国家重点研发计划子课题、浙江省自然科学基金重点项目等科研项目10余项，并与多家企业开展产学研合作。担任Scientific Reports、Clinical and Experimental Pharmacology and Physiology期刊编委；Regenerative Biomaterials、Biomaterials Translational等期刊青年编委。现任中国生物材料学会生物陶瓷分会委员、中国生物材料学会烧创伤创面修复材料分会委员、中国生物医学工程学会生物材料分会委员、中国抗癌协会纳米肿瘤学专业委员会青年委员。入选深圳市海外高层次人才、温州市“瓯越海智计划”青年人才。担任Nature Communications, Advanced Materials等期刊审稿人。
研究领域
（1）新型生物活性材料的设计与开发，包括纳米活性材料、有机/无机复合功能材料及微生物工程化活体生物材料。
（2）材料的生物学效应研究，聚焦材料与细胞或微生物的相互作用规律及分子机制。
（3）病理或衰老状态下的骨、软骨、心脏、皮肤、牙髓等难治性组织损伤的再生修复与功能重建。
近五年发表论文（#共同第一作者，*共同通讯作者）
1. Zhaoxu Meng#, Zhen Zeng#, Zhaowenbin Zhang, Lefeng Su, Huili Li, Chunlong Zhang, Hanjiao Chen, Xinyi Wang, Jiang Chang, Yingbo Wang*, Kui Luo*, Chen Yang*. Osteogenic nanozymes for diabetic bone regeneration via synergistic antioxidant and osteoinductive functions. Advanced Materials, 2026, 0, e72833.
2. Bo Li#, Dandan Jin#, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang*, Shixuan Chen*, Yi Zhang*. A “hot spring” mimetic aerogel loaded with multiple amino acids modulates the chronic inflammatory microenvironment through metabolic reprogramming. Advanced Science, 2026, 0, e22481.
3. Ruqi Wang#, Qishu Jin#, Zhaoxu Meng, Xiaodong Cao, Yihao Wu, Chen Yang*, Jiandong Yuan*. Baicalein-manganese nanoparticles for antioxidant and osteogenic therapy of bone injury. Colloids and Surfaces B: Biointerfaces, 2026, 260, 115400.
4. Chen Yang#*, Chenle Dong#, Lefeng Su#, Zhiqiang Liu#, Lingyi Hu, Qishu Jin, Hao Chen, Chunlong Zhang, Yihao Wu, Jiang Chang, Zhaowenbin Zhang*, Jiandong Yuan*. A universal metal-flavonoid coating strategy: Engineering biomaterials for diabetic bone regeneration. Advanced Science, 2026, 13, e22509.
5. Zhen Zeng#, Zhaowenbin Zhang#, Lan Chang, Hanjiao Chen, Long Reng, Zhiqiang Huang, Yiren Jiao, Hangbin Xia, Chen Yang*, Kui Luo*, Jiang Chang*. Therapeutic silicate biomaterials for sarcopenia treatment by inhibiting inflammation and enhancing muscle regeneration through regulation of Sarcolipin/SIRT signaling pathway. Bioactive Materials, 2025, 51, 787-806.
6. Ming Teng, Xiaomin Luo*, Jiang Chang*, Chen Yang, Xiaomeng Zhang, Liuying Li, Xudan Liu, Ruizhi Zhi, Xu Guo, Xinhua Liu*. Engineering encapsulated living bacteria for advanced healthcare management. Biotechnology Advances, 2025, 83, 108640.
7. Xuening Jin#, Yihao Wu#, Zheng Chen#, Fujin Zhou, Qishu Jin, Shuting Wu, Yanping Feng, Jianfeng Ma, Xiaohui Guo, Jiang Chang*, Chen Yang*, Botao Song*. Bioinspired nanofiber dressings with counter-transport of exudate and drug for treating heavily exuding wounds. Biomaterials, 2025, 317, 123084.
8. Xianwen Lu, Sitong Hu, Zhaowenbin Zhang, Jing Bao, Bangping Cao, Jian Xie, Jiang Chang, Chen Yang*, Xiaohong Wang*, Jiansheng Su*. A pH-sensitive CuHP composite hydrogel featuring antibacterial, antioxidant, and osteogenic properties for treating diabetic periodontitis. Regenerative Biomaterials, 2025, 12, rbaf065.
9. Chengxiao Liu#, Bin Yu#, Zhaowenbin Zhang#, Lefeng Su, Ruiqing Wang, Yu Jin, Weiming Guo, Ruomei Li, Zhen Zeng, Peng Mei, Jiang Chang, Lunguo Xia*, Chen Yang*, Bing Fang*. LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway. Biomaterials, 2025, 317, 123084.
10. Ping Sun#, Zhaowenbin Zhang#, Fei Gao, Chen Yang, Ge Mang, Shuai Fu, Jiawei Tian*, Jiang Chang*. Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting vicious cycle of immune inflammation via FOXO signaling. Science Advances, 2025, 11, eadr7208.
11. Jupei Zhang#, Hangbin Xia#, Xuerui Zhou#, Zhaoxu Meng, Qishu Jin, Dongmin Chen, Xiaojuan Xia, Yiren Jiao, Jiang Chang, Zhihong Dong*, Zhen Zeng*, Hongshi Ma*, Chen Yang*. 3D-Printed CoSi/PCL composite scaffold with NIR-II photothermal ability and enhanced adipogenic activity for breast reconstruction after mastectomy. Materials Today Bio, 2025, 31, 101577.
12. Dongmin Chen#, Xiaosheng Sheng#, Huili Li, Qishu Jin, Ruqi Wanga, Yuanzheng Qiu, Lefeng Su, Jinfeng Xu, Jiang Chang*, Yumei Que*, Chen Yang*. Biodegradable copper-containing mesoporous microspheres loaded with ginsenoside Rb1 for infarcted heart repair. Biomaterials Advances, 2025, 169, 214172.
13. Lian-Hua Fu#, Mengting Yin#, Xin Chen#, Chen Yang, Jing Lin, Xiansong Wang*, Baoguo Jiang*, and Peng Huang*. Targeted Management of Diabetic Osteoporosis by Biocatalytic Cascade Reaction Nanoplatform. Nano Letters, 2025, 25, 3075-3084.
14. Hangbin Xia#, Chen Yang#*, Huili Li#, Lingwei Huang, Zhen Zeng, Runrun Chi, Ziwei Yang, Yuzen Wang, Jiang Chang*, Yiren Jiao*, Wenzhong Li*. Combined magnesium and silicate ions synergistically promote functional regeneration of skeletal muscle by regulating satellite cell fate. Regenerative Biomaterials, 2025, 12, rbaf008.
15. Zizhao Chen#, Pingping Feng#, Ruqi Wang#, Dongmin Chen, Chunmei Feng, Qishu Jin, Chen Yang*, Botao Song*. Bioinspired shape-changing nanofiber dressings for intelligent wrapping and promoting healing of superficial wounds. Colloids and Surfaces B: Biointerfaces, 2025, 245, 114246.
16. Zhaowenbin Zhang#, Chen Fan#, Qing Xu#, Feng Guo#, Wenbo Li#, Zhen Zeng, Yuze Xu, Jing Yu, Hongping Ge, Chen Yang*, Jiang Chang*. A new strategy to inhibit scar formation by accelerating normal healing using silicate bioactive materials. Advanced Science, 2024, 11, 2407718.
17. Xiaomin Luo#*, Lufeng Ji, Fen Ao, Chen Yang, Jiang Chang, Changyu Yin, Huijun Ren, Ming Teng, Liuying Li, Xinhua Liu*. On-demand engineered double-network gelatin/silicate composited hydrogels with enhanced wet adhesion and stable release of bioactive ion for promoting wound healing. Collagen and Leather, 2024, 6, 18.
18. Pengli Wang#, Erji Gao#, Tao Wang#, Yanping Feng, Yong Xu, Lefeng Su, Wei Gao, Zheng Ci, Muhammad Rizwan Younis, Jiang Chang*, Chen Yang*, Liang Duan*. Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration. Journal of Nanobiotechnology, 2024, 22, 652.
19. Lili Sheng#, Yanping Feng#, Shuting Wu#, Chen Wang#, Ruiyang Sun, Qishu Jin, Dongmin Chen, Zhaowenbin Zhang, He Xu*, Zhihong Dong*, Hong Zhu*, Chen Yang*, Jiang Chang. Biodegradable copper vanadate-based hydrogel with photocatalytic/photothermal therapy for infected diabetic wound healing. Materials & Design, 2024, 246, 113358.
20. Lingwei Huan#, Yiren Jiao#, Hangbin Xia, Huili Li, Jing Yu, Yumei Que, Zhen Zeng, Chen Fan, Chen Wang, Chen Yang*, Jiang Chang*. Strontium zinc silicate simultaneously alleviates osteoporosis and sarcopenia in tail-suspended rats via Piezo1-mediated Ca2+ signaling. Journal of Orthopaedic Translation, 2024, 48, 146-155.
21. Zhaowenbin Zhang#, Di Chang#, Zhen Zeng, Yuze Xu, Jing Yu, Chen Fan, Chen Yang*, Jiang Chang*. CuCS/Cur composite wound dressings promote neuralized skin regeneration by rebuilding the nerve cell “factory” in deep skin burns. Materials Today Bio, 2024, 26, 101075.
22. Yumei Que#, Jiaxin Shi#, Zhaowenbin Zhang#, Lu Sun, Hairu Li, Xionghai Qin, Zhen Zeng, Xiao Yang, Yanxin Chen, Chong Liu, Chang Liu, Shijie Sun, Qishu Jin, Yanxin Zhang, Xin Li, Ming Lei, Chen Yang*, Hai Tian*, Jiawei Tian*, Jiang Chang*. Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling. Exploration, 2024, 4, 20230067.
23. Lefeng Su#, Chenle Dong#, Lei Liu#, Yanping Feng, Jinfeng Xu, Qinfei Ke1, Jiang Chang*, Chen Yang*, He Xu*. Low-temperature trigger nitric oxide nanogenerators for antibiofilm and wound healing. Advanced Fiber Materials, 2024, 6, 512-528.
24. Yanping Feng#, Lefeng Su#, Zhaowenbin Zhang#, Yanxin Chen, Muhammad Rizwan Younis, Dongmin Chen, Jinfeng Xu, Chenle Dong, Yumei Que, Chen Fan, Yiren Jiao, Hong Zhu, Jiang Chang*, Zhihong Dong*, Chen Yang*. pH-responsive wound dressing based on biodegradable CuP nanozymes for treating infected and diabetic wounds. ACS Applied Materials & Interfaces, 2024, 16, 95-110.
25. Yu Wang#, Yiren Jiao#, Zhen Zeng, Jiang Chang, Chen Yang*, Zhihong Dong*. Three-dimensional printed Zn2SiO4/sodium alginate composite scaffold with multiple biological functions for tendon-to-bone repair. MedComm-Biomaterials and Applications, 2023, 2, 61.
26. Jing Yu#, Yuze Xu#, Zhaowenbin Zhang#, Zhen Zeng, Dongmin Chen, Ziqin Wei, Endian Wang, Yanling Zhou, Chen Yang*, Jiang Chang*. Strontium zinc silicate bioceramic composite electrospun fiber membrane for hair follicle regeneration in burn wounds. Composites Part B-Engineering, 2023, 266, 110953.
27. Yu Qiu#, Jun Tian#, Siyi Kong, Yanping Feng, Yangyu Lu, Lefeng Su, Yanling Cai, Mengjie Li, Jiang Chang*, Chen Yang*, and Xi Wei*. SrCuSi4O10/GelMA Composite hydrogel-mediated vital pulp therapy: Integrating antibacterial property and enhanced pulp regeneration activity. Advanced Healthcare Materials, 2023, 2300546.
28. Nanjian Xu#, Dezhi Lu#, Lei Qiang#, Yihao Liu, Dalin Yin, Zhiyong Wang, Yongxiang Luo, Chen Yang, Zhenjiang Ma*, Hui Ma*, Jinwu Wang*. 3D-printed composite bioceramic scaffolds for bone and cartilage integrated regeneration. ACS Omega, 2023, 8, 37918-37926.
29. Yanxin Zhang, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng,* Chen Yang,* and Yumei Que*. Zn2SiO4 Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction. Advanced Healthcare Materials, 2023, 2203365.
30. Yumei Que, Zhaowenbin Zhang, Yanxin Zhang, Xin Li, Likai Chen, Peier Chen, Caiwen Ou, Chen Yang*, Jiang Chang*. Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection. Bioactive Materials, 2023, 25, 716-731.
31. Zhaowenbin Zhang#, Wenbo Li#, Di Chang, Ziqin Wei, Endian Wang, Jing Yu, Yuze Xu, Yumei Que, Yanxin Chen, Chen Fan, Bing Ma, Yanling Zhou, Zhiguang Huan, Chen Yang*, Feng Guo*, Jiang Chang*. A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch. Bioactive Materials, 2023, 24, 81-95.
32. Cancan Zhao#, Chen Yang#, Qun Lou, Jiashu Yan, Xudong Wang*, and Jiang Chang*. The memory effect of micro/nano- structures activating osteogenic differentiation of BMSCs. Journal of Materials Chemistry B, 2023, 11, 3816-3822.
33. Yanping Feng#, Mingzhen Wu#, Haidong Zhang, He Xu, Huili Li, Dongmin Chen, Hongyi Jiang, Jiang Chang, Zhihong Dong* and Chen Yang*. Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing. Frontiers in Bioengineering and Biotechnology, 2023, 11, 1158007.
34. Li Deng#, Lingwei Huang#, Hao Pan#, Qi Zhang, Yumei Que, Chen Fan, Jiang Chang*, Siyu Ni*, Chen Yang*. 3D printed strontium-zinc-phosphate bioceramic scaffolds with multiple biological functions for bone tissue regeneration. Journal of Materials Chemistry B, 2023, 11, 5469-5482.
35. Ye Yuan#, Zhaowenbin Zhang#, Fandi Mo#, Chen Yang, Yiren Jiao, Enci Wang, Yuchong Zhang, Peng Lin, Chengkai Hu, Weiguo Fu*, Jiang Chang*, Lixin Wang*. A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis. Bioactive Materials, 2023, 26, 264-278.
36. Jinfeng Xu#, Muhammad Rizwan Younis#, Zhaowenbin Zhang#, Yanping Feng, Lefeng Su, Yumei Que, Yiren Jiao, Chen Fan, Jiang Chang, Siyu Ni*, Chen Yang*. Mild heat-assisted polydopamine/alginate hydrogel containing low-dose nanoselenium for facilitating infected wound healing. ACS Applied Materials & Interfaces, 2023, 15, 7841-7854.
37. Xin Li, Yanxin Zhang, Qishu Jin, Qiaoyu Song, Chen Fan, Yiren Jiao, Chen Yang, Jiang Chang, Zhihong Dong*, Yumei Que*. Silicate ions derived from calcium silicate extract decelerate Ang II-induced cardiac remodeling. Tissue Engineering and Regenerative Medicine, 2023, 10.1007/s13770-023-00523-2.
38. Ruiqi Hao, Chun Wang, Chen Yang, Jiang Chang, Xiqiao Wang, Bo Yuan, Haiting Xu, Sen Zhou, Chen Fan*, Zhiming Li*. Transdermal delivery of Protocatechuic aldehyde using hyaluronic acid/ gelatin-based microneedles for the prevention and treatment of hypertrophic scars. European Journal of Pharmaceutics and Biopharmaceutics, 2023, 184, 202-213.
39. Jupei Zhang#, Zhen Zeng#, Yanxin Chen, Li Deng, Yanxin Zhang, Yumei Que, Yiren Jiao, Jiang Chang*, Zhihong Dong*, Chen Yang*. 3D-printed GelMA/CaSiO3 composite hydrogel scaffold for vascularized adipose tissue restoration. Regenerative Biomaterials, 2023, 10, rbad049.
40. Chen Fan, Qing Xu, Ruiqi Hao, Chun Wang, Yumei Que, Yanxin Chen, Chen Yang*, Jiang Chang*. Multi-functional wound dressings based on silicate bioactive materials. Biomaterials, 2022, 287, 121652.
41. Hongshi Ma#, Chen Yang#, Zhenjiang Ma#, Xiaoyue Wei, Muhammad Rizwan Younis, Hanbo Wang, Wentao Li, Zhiyong Wang, Wenhao Wanga, Yongxiang Luo*, Peng Huang*, Jinwu Wang*. Multiscale hierarchical architecture-based bioactive scaffolds for versatile tissue engineering. Advanced Healthcare Materials, 2022, 11, 2102837.
42. Chenle Dong#, Chen Yang#, Muhammad Rizwan Younis, Jing Zhang, Gang He, Xingdi Qiu, Lian-Hua Fu, Dong-Yang Zhang, Hao Wang, Wenli Hong, Jing Lin, Xueqing Wu*, Peng Huang*. Bioactive NIR-II light-responsive shape memory composite based on cuprorivaite nanosheets for endometrial regeneration. Advanced Science, 2022, 9, 2102220.
43. Qing Xu#, Feng Jiang#, Geyong Guo#, Endian Wang, MR Younis, Zhaowenbin Zhang, Feiyang Zhang, Zhiguang Huan, Chen Fan, Chen Yang*, Hao Shen*, Jiang Chang*. Targeted hot ion therapy of infected wound by glycol chitosan and polydopamine grafted Cu-SiO2 nanoparticles. Nano Today, 2021, 41, 101330.
44. Chen Yang#, Hongshi Ma#, Zhiyong Wang#, MR Younis, Chunyang Liu, Chengtie Wu*, Yongxiang Luo*, Peng Huang*. 3D printed wesselsite nanosheets functionalized scaffold facilitates NIR-II photothermal therapy and vascularized bone regeneration. Advanced Science, 2021, 8, 2100894.
45. Dong-Yang Zhang#, Hengke Liu#, Kathy S Zhu, Ting He, Muhammad Rizwan Younis, Chen Yang, Shan Lei, Jiayingzi Wu, Jing Lin, Junle Qu, Peng Huang*. Prussian blue-based theranostics for ameliorating acute kidney injury. Journal of Nanobiotechnology, 2021, 19, 266.
46. Dong-Yang Zhang#, Hengke Liu#, MR Younis, Shan Lei, Chen Yang, Jing Lin, Junle Qu, Peng Huang*. Ultrasmall platinum nanozymes as broad-spectrum antioxidants for theranostic application in acute kidney injury. Chemical Engineering Journal, 2021, 409, 127371.
47. Chen Yang#, Rui Zheng#, MR Younis, Jundong Shao, Lianhua Fu, Dongyang Zhang, Jing Lin, Zhiming Li*, Peng Huang*. NIR-II light-responsive biodegradable shape memory composites based on cuprorivaite nanosheets for enhanced tissue reconstruction. Chemical Engineering Journal, 2021, 419, 129437.
48. Chen Yang#, Zhiwei Zheng#, MR Younis, Chenle Dong, Yahong Chen, Shan Lei, Dongyang Zhang, Jiayingzi Wu, xueqing Wu, Jing Lin, Xiansong Wang*, Huang Peng*. 3D printed enzyme-functionalized scaffold facilitates diabetic bone regeneration. Advanced Functional Materials, 2021, 31, 2101372.
49. Chen Yang, Xiaoting Gao, MR Younis, TN Blum, Shan Lei, Dongyang Zhang, Yongxiang Luo, Peng Huang*, Lin Jing*. Non-invasive monitoring of in vivo bone regeneration based on alkaline phosphatase-responsive scaffolds. Chemical Engineering Journal, 2021, 408, 127959.
50. Lian-Hua Fu#, Yilin Wan#, Chao Qi#, Jin He, Chunying Li, Chen Yang, Han Xu, Jing Lin, Peng Huang*. Nanocatalytic theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient cancer therapy. Advanced Materials, 2021, 33, 2006892.
51. Dong-Yang Zhang#, Hengke Liu#, Chunying Li#, Muhammad Rizwan Younis, Shan Lei, Chen Yang, Jing Lin, Zhiming Li*, Peng Huang*. Ceria nanozymes with preferential renal uptake for acute kidney injury alleviation. ACS Applied Materials & Interfaces, 2020, 12, 51, 56830–56838.
52. Chen Yang, TN Blum, Jing Lin, Junle Qu, Peng Huang*. Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy. Science Bulletin, 2020, 65(17), 1489-1504.
53. Dong-Yang Zhang#, Hengke Liu#, Ting He, MR Younis, Tianhui Tu, Chen Yang, Jing Zhang, Jing Lin, Junle Qu, Peng Huang*. Biodegradable Self-Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury. Small, 2020, 16, 2001518.
54. Chen Yang, MR Younis, Jing Zhang, Junle Qu, Jing Lin, Peng Huang*. Programmable NIR-II photothermal-enhanced starvation-primed chemodynamic therapy using glucose oxidase-functionalized ancient pigment nanosheets. Small, 2020, 16, 2001518.
